Glyoxalase I, also known as GLO1, is a human gene.cite web | title = Entrez Gene: GLO1 glyoxalase I| url =| accessdate = ] It is a Lactoylglutathione lyase.

section_title =
summary_text = The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.cite web | title = Entrez Gene: GLO1 glyoxalase I| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Reinsmoen NL, Friend PS, Miller WV, "et al." |title=Inheritance of recombinant HLA-GLO haplotype suggesting the gene sequence. |journal=Nature |volume=267 |issue= 5608 |pages= 276–8 |year= 1977 |pmid= 141008 |doi=
*cite journal | author=Hansen HE, Eriksen B |title=HLA-GLO linkage analysis in 57 informative families. |journal=Hum. Hered. |volume=29 |issue= 6 |pages= 355–60 |year= 1980 |pmid= 511191 |doi=
*cite journal | author=Meo T, Douglas T, Rijnbeek AM |title=Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2. |journal=Science |volume=198 |issue= 4314 |pages= 311–3 |year= 1977 |pmid= 910130 |doi=
*cite journal | author=Kömpf J, Bissbort S, Gussmann S, Ritter H |title=Polymorphism of red cell glyoxalase I (EI:; a new genetic marker in man. Investigation of 169 mother-child combinations. |journal=Humangenetik |volume=27 |issue= 2 |pages= 141–3 |year= 1975 |pmid= 1150236 |doi=
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Goldman D, O'Brien SJ, Lucas-Derse S, Dean M |title=Linkage mapping of human polymorphic proteins identified by two-dimensional electrophoresis. |journal=Genomics |volume=11 |issue= 4 |pages= 875–84 |year= 1992 |pmid= 1686020 |doi=
*cite journal | author=Kim NS, Umezawa Y, Ohmura S, Kato S |title=Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida. |journal=J. Biol. Chem. |volume=268 |issue= 15 |pages= 11217–21 |year= 1993 |pmid= 7684374 |doi=
*cite journal | author=Ranganathan S, Walsh ES, Godwin AK, Tew KD |title=Cloning and characterization of human colon glyoxalase-I. |journal=J. Biol. Chem. |volume=268 |issue= 8 |pages= 5661–7 |year= 1993 |pmid= 8449929 |doi=
*cite journal | author=Ridderström M, Mannervik B |title=Optimized heterologous expression of the human zinc enzyme glyoxalase I. |journal=Biochem. J. |volume=314 ( Pt 2) |issue= |pages= 463–7 |year= 1996 |pmid= 8670058 |doi=
*cite journal | author=Cameron AD, Olin B, Ridderström M, "et al." |title=Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping. |journal=EMBO J. |volume=16 |issue= 12 |pages= 3386–95 |year= 1997 |pmid= 9218781 |doi= 10.1093/emboj/16.12.3386
*cite journal | author=Armeni T, Pieri C, Marra M, "et al." |title=Studies on the life prolonging effect of food restriction: glutathione levels and glyoxalase enzymes in rat liver. |journal=Mech. Ageing Dev. |volume=101 |issue= 1-2 |pages= 101–10 |year= 1998 |pmid= 9593316 |doi=
*cite journal | author=Ridderström M, Cameron AD, Jones TA, Mannervik B |title=Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21623–8 |year= 1998 |pmid= 9705294 |doi=
*cite journal | author=Cameron AD, Ridderström M, Olin B, "et al." |title=Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. |journal=Biochemistry |volume=38 |issue= 41 |pages= 13480–90 |year= 1999 |pmid= 10521255 |doi=
*cite journal | author=Ranganathan S, Ciaccio PJ, Walsh ES, Tew KD |title=Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation. |journal=Gene |volume=240 |issue= 1 |pages= 149–55 |year= 2000 |pmid= 10564821 |doi=
*cite journal | author=Sakamoto H, Mashima T, Kizaki A, "et al." |title=Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis. |journal=Blood |volume=95 |issue= 10 |pages= 3214–8 |year= 2000 |pmid= 10807791 |doi=
*cite journal | author=Sakamoto H, Mashima T, Sato S, "et al." |title=Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells. |journal=Clin. Cancer Res. |volume=7 |issue= 8 |pages= 2513–8 |year= 2001 |pmid= 11489834 |doi=
*cite journal | author=Lupidi G, Venardi G, Bollettini M, "et al." |title=Purification and partial characterization of glyoxalase I from bovine brain. |journal=Prep. Biochem. Biotechnol. |volume=31 |issue= 3 |pages= 305–16 |year= 2002 |pmid= 11513094 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Vander Jagt DL, Hunsaker LA |title=Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase. |journal=Chem. Biol. Interact. |volume=143-144 |issue= |pages= 341–51 |year= 2003 |pmid= 12604221 |doi=
*cite journal | author=Sergeev AS, Agapova RK, Bogadel'nikova IV, Perel'man MI |title= [The use of discrete characters in discriminant analysis for diagnosis of pulmonary tuberculosis and for classification of patients differing in treatment efficiency based on polymorphisms at nine codominant loci-HP, GC, TF, PI, PGM1, GLO1, C3, ACP1 and ESD] |journal=Genetika |volume=39 |issue= 7 |pages= 996–1002 |year= 2003 |pmid= 12942785 |doi=

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