SYN1

Synapsin I, also known as SYN1, is a human gene.cite web | title = Entrez Gene: SYN1 synapsin I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6853| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: SYN1 synapsin I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6853| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Südhof TC, Czernik AJ, Kao HT, "et al." |title=Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins. |journal=Science |volume=245 |issue= 4925 |pages= 1474–80 |year= 1989 |pmid= 2506642 |doi=
*cite journal | author=Greengard P, Valtorta F, Czernik AJ, Benfenati F |title=Synaptic vesicle phosphoproteins and regulation of synaptic function. |journal=Science |volume=259 |issue= 5096 |pages= 780–5 |year= 1993 |pmid= 8430330 |doi=
*cite journal | author=Kirchgessner CU, Trofatter JA, Mahtani MM, "et al." |title=A highly polymorphic dinucleotide repeat on the proximal short arm of the human X chromosome: linkage mapping of the synapsin I/A-raf-1 genes. |journal=Am. J. Hum. Genet. |volume=49 |issue= 1 |pages= 184–91 |year= 1991 |pmid= 1905878 |doi=
*cite journal | author=Bennett AF, Hayes NV, Baines AJ |title=Site specificity in the interactions of synapsin 1 with tubulin. |journal=Biochem. J. |volume=276 ( Pt 3) |issue= |pages= 793–9 |year= 1991 |pmid= 1905928 |doi=
*cite journal | author=Südhof TC |title=The structure of the human synapsin I gene and protein. |journal=J. Biol. Chem. |volume=265 |issue= 14 |pages= 7849–52 |year= 1990 |pmid= 2110562 |doi=
*cite journal | author=Sauerwald A, Hoesche C, Oschwald R, Kilimann MW |title=The 5'-flanking region of the synapsin I gene. A G+C-rich, TATA- and CAAT-less, phylogenetically conserved sequence with cell type-specific promoter function. |journal=J. Biol. Chem. |volume=265 |issue= 25 |pages= 14932–7 |year= 1990 |pmid= 2118519 |doi=
*cite journal | author=Yang-Feng TL, DeGennaro LJ, Francke U |title=Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 22 |pages= 8679–83 |year= 1986 |pmid= 3095840 |doi=
*cite journal | author=Czernik AJ, Pang DT, Greengard P |title=Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 21 |pages= 7518–22 |year= 1987 |pmid= 3118371 |doi=
*cite journal | author=McPherson PS, Czernik AJ, Chilcote TJ, "et al." |title=Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6486–90 |year= 1994 |pmid= 8022809 |doi=
*cite journal | author=Smith TW, Nikulasson S, De Girolami U, De Gennaro LJ |title=Immunohistochemistry of synapsin I and synaptophysin in human nervous system and neuroendocrine tumors. Applications in diagnostic neuro-oncology. |journal=Clin. Neuropathol. |volume=12 |issue= 6 |pages= 335–42 |year= 1994 |pmid= 8287627 |doi=
*cite journal | author=Matsubara M, Kusubata M, Ishiguro K, "et al." |title=Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions. |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21108–13 |year= 1996 |pmid= 8702879 |doi=
*cite journal | author=Chin D, Winkler KE, Means AR |title=Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31235–40 |year= 1998 |pmid= 9395448 |doi=
*cite journal | author=Witke W, Podtelejnikov AV, Di Nardo A, "et al." |title=In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. |journal=EMBO J. |volume=17 |issue= 4 |pages= 967–76 |year= 1998 |pmid= 9463375 |doi= 10.1093/emboj/17.4.967
*cite journal | author=Kimoto Y |title=A single human cell expresses all messenger ribonucleic acids: the arrow of time in a cell. |journal=Mol. Gen. Genet. |volume=258 |issue= 3 |pages= 233–9 |year= 1998 |pmid= 9645429 |doi=
*cite journal | author=Hosaka M, Südhof TC |title=Homo- and heterodimerization of synapsins. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16747–53 |year= 1999 |pmid= 10358015 |doi=
*cite journal | author=Cole RN, Hart GW |title=Glycosylation sites flank phosphorylation sites on synapsin I: O-linked N-acetylglucosamine residues are localized within domains mediating synapsin I interactions. |journal=J. Neurochem. |volume=73 |issue= 1 |pages= 418–28 |year= 1999 |pmid= 10386995 |doi=
*cite journal | author=Hosaka M, Hammer RE, Südhof TC |title=A phospho-switch controls the dynamic association of synapsins with synaptic vesicles. |journal=Neuron |volume=24 |issue= 2 |pages= 377–87 |year= 1999 |pmid= 10571231 |doi=
*cite journal | author=Kao HT, Porton B, Hilfiker S, "et al." |title=Molecular evolution of the synapsin gene family. |journal=J. Exp. Zool. |volume=285 |issue= 4 |pages= 360–77 |year= 2000 |pmid= 10578110 |doi=

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