IL1RL1

Interleukin 1 receptor-like 1, also known as IL1RL1, is a human gene.cite web | title = Entrez Gene: IL1RL1 interleukin 1 receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9173| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.cite web | title = Entrez Gene: IL1RL1 interleukin 1 receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9173| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tominaga S, Yokota T, Yanagisawa K, "et al." |title=Nucleotide sequence of a complementary DNA for human ST2. |journal=Biochim. Biophys. Acta |volume=1171 |issue= 2 |pages= 215–8 |year= 1993 |pmid= 1482686 |doi=
*cite journal | author=Gayle MA, Slack JL, Bonnert TP, "et al." |title=Cloning of a putative ligand for the T1/ST2 receptor. |journal=J. Biol. Chem. |volume=271 |issue= 10 |pages= 5784–9 |year= 1996 |pmid= 8621446 |doi=
*cite journal | author=Yanagisawa K, Naito Y, Kuroiwa K, "et al." |title=The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells. |journal=J. Biochem. |volume=121 |issue= 1 |pages= 95–103 |year= 1997 |pmid= 9058198 |doi=
*cite journal | author=Kumar S, Tzimas MN, Griswold DE, Young PR |title=Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 474–8 |year= 1997 |pmid= 9207179 |doi= 10.1006/bbrc.1997.6810
*cite journal | author=Löhning M, Stroehmann A, Coyle AJ, "et al." |title=T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6930–5 |year= 1998 |pmid= 9618516 |doi=
*cite journal | author=Moritz DR, Rodewald HR, Gheyselinck J, Klemenz R |title=The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors. |journal=J. Immunol. |volume=161 |issue= 9 |pages= 4866–74 |year= 1998 |pmid= 9794420 |doi=
*cite journal | author=Saccani S, Polentarutti N, Penton-Rol G, "et al." |title=Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo. |journal=Cytokine |volume=10 |issue= 10 |pages= 773–80 |year= 1999 |pmid= 9811530 |doi= 10.1006/cyto.1998.0359
*cite journal | author=Dale M, Nicklin MJ |title=Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. |journal=Genomics |volume=57 |issue= 1 |pages= 177–9 |year= 1999 |pmid= 10191101 |doi= 10.1006/geno.1999.5767
*cite journal | author=Iwahana H, Yanagisawa K, Ito-Kosaka A, "et al." |title=Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells. |journal=Eur. J. Biochem. |volume=264 |issue= 2 |pages= 397–406 |year= 1999 |pmid= 10491084 |doi=
*cite journal | author=Tominaga S, Kuroiwa K, Tago K, "et al." |title=Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 1 |pages= 14–8 |year= 1999 |pmid= 10527832 |doi= 10.1006/bbrc.1999.1469
*cite journal | author=Li H, Tago K, Io K, "et al." |title=The cloning and nucleotide sequence of human ST2L cDNA. |journal=Genomics |volume=67 |issue= 3 |pages= 284–90 |year= 2000 |pmid= 10936050 |doi= 10.1006/geno.2000.6269
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Sweet MJ, Leung BP, Kang D, "et al." |title=A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. |journal=J. Immunol. |volume=166 |issue= 11 |pages= 6633–9 |year= 2001 |pmid= 11359817 |doi=
*cite journal | author=Tago K, Noda T, Hayakawa M, "et al." |title=Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V. |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 5 |pages= 1377–83 |year= 2001 |pmid= 11478810 |doi= 10.1006/bbrc.2001.5306
*cite journal | author=Lécart S, Lecointe N, Subramaniam A, "et al." |title=Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface. |journal=Eur. J. Immunol. |volume=32 |issue= 10 |pages= 2979–87 |year= 2002 |pmid= 12355452 |doi= 10.1002/1521-4141(2002010)32:10<2979::AID-IMMU2979>3.0.CO;2-5 |doilabel=10.1002/1521-4141(2002010)32:102979::AID-IMMU29793.0.CO;2-5
*cite journal | author=Brint EK, Fitzgerald KA, Smith P, "et al." |title=Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49205–11 |year= 2003 |pmid= 12368275 |doi= 10.1074/jbc.M209685200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Haga Y, Yanagisawa K, Ohto-Ozaki H, "et al." |title=The effect of ST2 gene product on anchorage-independent growth of a glioblastoma cell line, T98G. |journal=Eur. J. Biochem. |volume=270 |issue= 1 |pages= 163–70 |year= 2003 |pmid= 12492487 |doi=
*cite journal | author=Weinberg EO, Shimpo M, Hurwitz S, "et al." |title=Identification of serum soluble ST2 receptor as a novel heart failure biomarker. |journal=Circulation |volume=107 |issue= 5 |pages= 721–6 |year= 2003 |pmid= 12578875 |doi=
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810

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