HRG (gene)

HRG (gene)

Histidine-rich glycoprotein, also known as HRG, is a human gene.cite web | title = Entrez Gene: HRG histidine-rich glycoprotein| url =| accessdate = ]

section_title =
summary_text = This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.cite web | title = Entrez Gene: HRG histidine-rich glycoprotein| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Hughes GJ, Frutiger S, Paquet N, "et al." |title=Plasma protein
journal=Electrophoresis |volume=13 |issue= 9-10 |pages= 707–14 |year= 1993 |pmid= 1459097 |doi=

*cite journal | author=Hutchens TW, Yip TT, Morgan WT |title=Identification of histidine-rich glycoprotein in human colostrum and milk. |journal=Pediatr. Res. |volume=31 |issue= 3 |pages= 239–46 |year= 1992 |pmid= 1561009 |doi=
*cite journal | author=Hennis BC, Kluft C |title=KpnI RFLP in the human histidine-rich glycoprotein gene. |journal=Nucleic Acids Res. |volume=19 |issue= 15 |pages= 4311 |year= 1991 |pmid= 1678514 |doi=
*cite journal | author=van den Berg EA, le Clercq E, Kluft C, "et al." |title=Assignment of the human gene for histidine-rich glycoprotein to chromosome 3. |journal=Genomics |volume=7 |issue= 2 |pages= 276–9 |year= 1990 |pmid= 2347592 |doi=
*cite journal | author=Shatsky M, Saigo K, Burdach S, "et al." |title=Histidine-rich glycoprotein blocks T cell rosette formation and modulates both T cell activation and immunoregulation. |journal=J. Biol. Chem. |volume=264 |issue= 14 |pages= 8254–9 |year= 1989 |pmid= 2524479 |doi=
*cite journal | author=Saigo K, Shatsky M, Levitt LJ, Leung LK |title=Interaction of histidine-rich glycoprotein with human T lymphocytes. |journal=J. Biol. Chem. |volume=264 |issue= 14 |pages= 8249–53 |year= 1989 |pmid= 2566603 |doi=
*cite journal | author=Koide T, Foster D, Yoshitake S, Davie EW |title=Amino acid sequence of human histidine-rich glycoprotein derived from the nucleotide sequence of its cDNA. |journal=Biochemistry |volume=25 |issue= 8 |pages= 2220–5 |year= 1986 |pmid= 3011081 |doi=
*cite journal | author=Hajjar DP, Boyd DB, Harpel PC, Nachman RL |title=Histidine-rich glycoprotein inhibits the antiproliferative effect of heparin on smooth muscle cells. |journal=J. Exp. Med. |volume=165 |issue= 3 |pages= 908–13 |year= 1987 |pmid= 3819648 |doi=
*cite journal | author=Leung LL |title=Interaction of histidine-rich glycoprotein with fibrinogen and fibrin. |journal=J. Clin. Invest. |volume=77 |issue= 4 |pages= 1305–11 |year= 1986 |pmid= 3958188 |doi=
*cite journal | author=Heimburger N, Haupt H, Kranz T, Baudner S |title= [Human serum proteins with high affinity to carboxymethylcellulose. II. Physico-chemical and immunological characterization of a histidine-rich 3,8S- 2 -glycoportein (CM-protein I)] |journal=Hoppe-Seyler's Z. Physiol. Chem. |volume=353 |issue= 7 |pages= 1133–40 |year= 1972 |pmid= 4116337 |doi=
*cite journal | author=Silverstein RL, Leung LL, Harpel PC, Nachman RL |title=Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. |journal=J. Clin. Invest. |volume=74 |issue= 5 |pages= 1625–33 |year= 1984 |pmid= 6438154 |doi=
*cite journal | author=Hennis BC, Frants RR, Bakker E, "et al." |title=Evidence for the absence of intron H of the histidine-rich glycoprotein (HRG) gene: genetic mapping and in situ localization of HRG to chromosome 3q28-q29. |journal=Genomics |volume=19 |issue= 1 |pages= 195–7 |year= 1994 |pmid= 8188234 |doi= 10.1006/geno.1994.1046
*cite journal | author=Sørensen CB, Krogh-Pedersen H, Petersen TE |title=Determination of the disulphide bridge arrangement of bovine histidine-rich glycoprotein. |journal=FEBS Lett. |volume=328 |issue= 3 |pages= 285–90 |year= 1993 |pmid= 8348977 |doi=
*cite journal | author=Leung L |title=Histidine-rich glycoprotein: an abundant plasma protein in search of a function. |journal=J. Lab. Clin. Med. |volume=121 |issue= 5 |pages= 630–1 |year= 1993 |pmid= 8478589 |doi=
*cite journal | author=Angles-Cano E, Gris JC, Loyau S, Schved JF |title=Familial association of high levels of histidine-rich glycoprotein and plasminogen activator inhibitor-1 with venous thromboembolism. |journal=J. Lab. Clin. Med. |volume=121 |issue= 5 |pages= 646–53 |year= 1993 |pmid= 8478593 |doi=
*cite journal | author=Gorgani NN, Parish CR, Easterbrook Smith SB, Altin JG |title=Histidine-rich glycoprotein binds to human IgG and C1q and inhibits the formation of insoluble immune complexes. |journal=Biochemistry |volume=36 |issue= 22 |pages= 6653–62 |year= 1997 |pmid= 9184145 |doi= 10.1021/bi962573n
*cite journal | author=Schinke T, Koide T, Jahnen-Dechent W |title=Human histidine-rich glycoprotein expressed in SF9 insect cells inhibits apatite formation. |journal=FEBS Lett. |volume=412 |issue= 3 |pages= 559–62 |year= 1997 |pmid= 9276466 |doi=
*cite journal | author=Shigekiyo T, Yoshida H, Matsumoto K, "et al." |title=HRG Tokushima: molecular and cellular characterization of histidine-rich glycoprotein (HRG) deficiency. |journal=Blood |volume=91 |issue= 1 |pages= 128–33 |year= 1998 |pmid= 9414276 |doi=
*cite journal | author=Wakabayashi S, Takahashi K, Koide T |title=Structural characterization of the gene for human histidine-rich glycoprotein, reinvestigation of the 5'-terminal region of cDNA and a search for the liver specific promoter in the gene. |journal=J. Biochem. |volume=125 |issue= 3 |pages= 522–30 |year= 1999 |pmid= 10050040 |doi=
*cite journal | author=Gorgani NN, Altin JG, Parish CR |title=Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes. |journal=Int. Immunol. |volume=11 |issue= 8 |pages= 1275–82 |year= 1999 |pmid= 10421785 |doi=

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