AHSG

Alpha-2-HS-glycoprotein, also known as AHSG, is a human gene.cite web | title = Entrez Gene: AHSG alpha-2-HS-glycoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=197| accessdate = ]

PBB_Summary
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summary_text = Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure.cite web | title = Entrez Gene: AHSG alpha-2-HS-glycoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=197| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ketteler M, Vermeer C, Wanner C, "et al." |title=Novel insights into uremic vascular calcification: role of matrix Gla protein and alpha-2-Heremans Schmid glycoprotein/fetuin. |journal=Blood Purif. |volume=20 |issue= 5 |pages= 473–6 |year= 2003 |pmid= 12207096 |doi=
*cite journal | author=Ketteler M |title=Fetuin-A and extraosseous calcification in uremia. |journal=Curr. Opin. Nephrol. Hypertens. |volume=14 |issue= 4 |pages= 337–42 |year= 2005 |pmid= 15931001 |doi=
*cite journal | author=Yang F, Schwartz Z, Swain LD, "et al." |title=Alpha 2-HS-glycoprotein: expression in chondrocytes and augmentation of alkaline phosphatase and phospholipase A2 activity. |journal=Bone |volume=12 |issue= 1 |pages= 7–15 |year= 1991 |pmid= 2054237 |doi=
*cite journal | author=Araki T, Yoshioka Y, Schmid K |title=The position of the disulfide bonds in human plasma alpha 2 HS-glycoprotein and the repeating double disulfide bonds in the domain structure. |journal=Biochim. Biophys. Acta |volume=994 |issue= 3 |pages= 195–9 |year= 1989 |pmid= 2645941 |doi=
*cite journal | author=Kellermann J, Haupt H, Auerswald EA, Müller-Ester W |title=The arrangement of disulfide loops in human alpha 2-HS glycoprotein. Similarity to the disulfide bridge structures of cystatins and kininogens. |journal=J. Biol. Chem. |volume=264 |issue= 24 |pages= 14121–8 |year= 1989 |pmid= 2760061 |doi=
*cite journal | author=Magnuson VL, McCombs JL, Lee CC, "et al." |title=Human alpha 2-HS-glycoprotein localized to 3q27----q29 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=47 |issue= 1-2 |pages= 72–4 |year= 1988 |pmid= 3356172 |doi=
*cite journal | author=Lee CC, Bowman BH, Yang FM |title=Human alpha 2-HS-glycoprotein: the A and B chains with a connecting sequence are encoded by a single mRNA transcript. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 13 |pages= 4403–7 |year= 1987 |pmid= 3474608 |doi=
*cite journal | author=Keeley FW, Sitarz EE |title=Identification and quantitation of alpha 2-HS-glycoprotein in the mineralized matrix of calcified plaques of atherosclerotic human aorta. |journal=Atherosclerosis |volume=55 |issue= 1 |pages= 63–9 |year= 1985 |pmid= 3924066 |doi=
*cite journal | author=Yoshioka Y, Gejyo F, Marti T, "et al." |title=The complete amino acid sequence of the A-chain of human plasma alpha 2HS-glycoprotein. |journal=J. Biol. Chem. |volume=261 |issue= 4 |pages= 1665–76 |year= 1986 |pmid= 3944104 |doi=
*cite journal | author=Matsushima K, Cheng M, Migita S |title=Purification and physicochemical characterization of human alpha 2-HS-glycoprotein. |journal=Biochim. Biophys. Acta |volume=701 |issue= 2 |pages= 200–5 |year= 1982 |pmid= 6803836 |doi=
*cite journal | author=Gejyo F, Chang JL, Bürgi W, "et al." |title=Characterization of the B-chain of human plasma alpha 2HS-glycoprotein. The complete amino acid sequence and primary structure of its heteroglycan. |journal=J. Biol. Chem. |volume=258 |issue= 8 |pages= 4966–71 |year= 1983 |pmid= 6833285 |doi=
*cite journal | author=Rizzu P, Baldini A |title=Three members of the human cystatin gene superfamily, AHSG, HRG, and KNG, map within one megabase of genomic DNA at 3q27. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 1-2 |pages= 26–8 |year= 1995 |pmid= 7736783 |doi=
*cite journal | author=Srinivas PR, Wagner AS, Reddy LV, "et al." |title=Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. |journal=Mol. Endocrinol. |volume=7 |issue= 11 |pages= 1445–55 |year= 1994 |pmid= 7906861 |doi=
*cite journal | author=Nawratil P, Lenzen S, Kellermann J, "et al." |title=Limited proteolysis of human alpha2-HS glycoprotein/fetuin. Evidence that a chymotryptic activity can release the connecting peptide. |journal=J. Biol. Chem. |volume=271 |issue= 49 |pages= 31735–41 |year= 1997 |pmid= 8940198 |doi=
*cite journal | author=Osawa M, Umetsu K, Ohki T, "et al." |title=Molecular evidence for human alpha 2-HS glycoprotein (AHSG) polymorphism. |journal=Hum. Genet. |volume=99 |issue= 1 |pages= 18–21 |year= 1997 |pmid= 9003486 |doi=
*cite journal | author=Osawa M, Umetsu K, Sato M, "et al." |title=Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). |journal=Gene |volume=196 |issue= 1-2 |pages= 121–5 |year= 1997 |pmid= 9322749 |doi=
*cite journal | author=Umekawa T, Iguchi M, Konya E, "et al." |title=Localization and inhibitory activity of alpha(2)HS-glycoprotein in the kidney. |journal=Urol. Res. |volume=27 |issue= 5 |pages= 315–8 |year= 2000 |pmid= 10550518 |doi=
*cite journal | author=Olivier E, Soury E, Ruminy P, "et al." |title=Fetuin-B, a second member of the fetuin family in mammals. |journal=Biochem. J. |volume=350 Pt 2 |issue= |pages= 589–97 |year= 2001 |pmid= 10947975 |doi=
*cite journal | author=Osawa M, Yuasa I, Kitano T, "et al." |title=Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene. |journal=Ann. Hum. Genet. |volume=65 |issue= Pt 1 |pages= 27–34 |year= 2001 |pmid= 11415520 |doi=
*cite journal | author=Haglund AC, Ek B, Ek P |title=Phosphorylation of human plasma alpha2-Heremans-Schmid glycoprotein (human fetuin) in vivo. |journal=Biochem. J. |volume=357 |issue= Pt 2 |pages= 437–45 |year= 2001 |pmid= 11439093 |doi=

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