Cylindromatosis

Cylindromatosis (turban tumor syndrome), also known as CYLD, is a human gene.cite web | title = Entrez Gene: CYLD cylindromatosis (turban tumor syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1540| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: CYLD cylindromatosis (turban tumor syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1540| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Lian F, Cockerell CJ |title=Cutaneous appendage tumors: familial cylindromatosis and associated tumors update. |journal=Advances in dermatology |volume=21 |issue= |pages= 217–34 |year= 2006 |pmid= 16350444 |doi=
*cite journal | author=Biggs PJ, Wooster R, Ford D, "et al." |title=Familial cylindromatosis (turban tumour syndrome) gene localised to chromosome 16q12-q13: evidence for its role as a tumour suppressor gene. |journal=Nat. Genet. |volume=11 |issue= 4 |pages= 441–3 |year= 1996 |pmid= 7493027 |doi= 10.1038/ng1295-441
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Biggs PJ, Chapman P, Lakhani SR, "et al." |title=The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas. |journal=Oncogene |volume=12 |issue= 6 |pages= 1375–7 |year= 1996 |pmid= 8649842 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=
*cite journal | author=Thomson SA, Rasmussen SA, Zhang J, Wallace MR |title=A new hereditary cylindromatosis family associated with CYLD1 on chromosome 16. |journal=Hum. Genet. |volume=105 |issue= 1-2 |pages= 171–3 |year= 1999 |pmid= 10480375 |doi=
*cite journal | author=Bignell GR, Warren W, Seal S, "et al." |title=Identification of the familial cylindromatosis tumour-suppressor gene. |journal=Nat. Genet. |volume=25 |issue= 2 |pages= 160–5 |year= 2000 |pmid= 10835629 |doi= 10.1038/76006
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Trompouki E, Hatzivassiliou E, Tsichritzis T, "et al." |title=CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. |journal=Nature |volume=424 |issue= 6950 |pages= 793–6 |year= 2003 |pmid= 12917689 |doi= 10.1038/nature01803
*cite journal | author=Brummelkamp TR, Nijman SM, Dirac AM, Bernards R |title=Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. |journal=Nature |volume=424 |issue= 6950 |pages= 797–801 |year= 2003 |pmid= 12917690 |doi= 10.1038/nature01811
*cite journal | author=Kovalenko A, Chable-Bessia C, Cantarella G, "et al." |title=The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. |journal=Nature |volume=424 |issue= 6950 |pages= 801–5 |year= 2003 |pmid= 12917691 |doi= 10.1038/nature01802
*cite journal | author=Hu G, Onder M, Gill M, "et al." |title=A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome. |journal=J. Invest. Dermatol. |volume=121 |issue= 4 |pages= 732–4 |year= 2003 |pmid= 14632188 |doi= 10.1046/j.1523-1747.2003.12514.x
*cite journal | author=Regamey A, Hohl D, Liu JW, "et al." |title=The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. |journal=J. Exp. Med. |volume=198 |issue= 12 |pages= 1959–64 |year= 2004 |pmid= 14676304 |doi= 10.1084/jem.20031187
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Zhang XJ, Liang YH, He PP, "et al." |title=Identification of the cylindromatosis tumor-suppressor gene responsible for multiple familial trichoepithelioma. |journal=J. Invest. Dermatol. |volume=122 |issue= 3 |pages= 658–64 |year= 2004 |pmid= 15086550 |doi= 10.1111/j.0022-202X.2004.22321.x
*cite journal | author=Jono H, Lim JH, Chen LF, "et al." |title=NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway. |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36171–4 |year= 2004 |pmid= 15226292 |doi= 10.1074/jbc.M406638200

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