ST14

Suppression of tumorigenicity 14 (colon carcinoma), also known as ST14, is a human gene.cite web | title = Entrez Gene: ST14 suppression of tumorigenicity 14 (colon carcinoma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6768| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scatter factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.cite web | title = Entrez Gene: ST14 suppression of tumorigenicity 14 (colon carcinoma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6768| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Uhland K |title=Matriptase and its putative role in cancer. |journal=Cell. Mol. Life Sci. |volume=63 |issue= 24 |pages= 2968–78 |year= 2007 |pmid= 17131055 |doi= 10.1007/s00018-006-6298-x
*cite journal | author=Zhang Y, Cai X, Schlegelberger B, Zheng S |title=Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24-->q25 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 1-2 |pages= 56–7 |year= 1999 |pmid= 9925927 |doi=
*cite journal | author=Lin CY, Anders J, Johnson M, "et al." |title=Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18231–6 |year= 1999 |pmid= 10373424 |doi=
*cite journal | author=Lin CY, Anders J, Johnson M, Dickson RB |title=Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18237–42 |year= 1999 |pmid= 10373425 |doi=
*cite journal | author=Takeuchi T, Shuman MA, Craik CS |title=Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11054–61 |year= 1999 |pmid= 10500122 |doi=
*cite journal | author=Takeuchi T, Harris JL, Huang W, "et al." |title=Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26333–42 |year= 2000 |pmid= 10831593 |doi= 10.1074/jbc.M002941200
*cite journal | author=Lee SL, Dickson RB, Lin CY |title=Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 36720–5 |year= 2001 |pmid= 10962009 |doi= 10.1074/jbc.M007802200
*cite journal | author=Tanimoto H, Underwood LJ, Wang Y, "et al." |title=Ovarian tumor cells express a transmembrane serine protease: a potential candidate for early diagnosis and therapeutic intervention. |journal=Tumour Biol. |volume=22 |issue= 2 |pages= 104–14 |year= 2001 |pmid= 11125283 |doi=
*cite journal | author=Oberst M, Anders J, Xie B, "et al." |title=Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. |journal=Am. J. Pathol. |volume=158 |issue= 4 |pages= 1301–11 |year= 2001 |pmid= 11290548 |doi=
*cite journal | author=Benaud C, Oberst M, Hobson JP, "et al." |title=Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10539–46 |year= 2002 |pmid= 11792696 |doi= 10.1074/jbc.M109064200
*cite journal | author=Ihara S, Miyoshi E, Ko JH, "et al." |title=Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16960–7 |year= 2002 |pmid= 11864986 |doi= 10.1074/jbc.M200673200
*cite journal | author=Peek M, Moran P, Mendoza N, "et al." |title=Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47804–9 |year= 2003 |pmid= 12372819 |doi= 10.1074/jbc.M209778200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Benaud CM, Oberst M, Dickson RB, Lin CY |title=Deregulated activation of matriptase in breast cancer cells. |journal=Clin. Exp. Metastasis |volume=19 |issue= 7 |pages= 639–49 |year= 2003 |pmid= 12498394 |doi=
*cite journal | author=Oberst MD, Williams CA, Dickson RB, "et al." |title=The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26773–9 |year= 2003 |pmid= 12738778 |doi= 10.1074/jbc.M304282200
*cite journal | author=Santin AD, Cane' S, Bellone S, "et al." |title=The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma. |journal=Cancer |volume=98 |issue= 9 |pages= 1898–904 |year= 2003 |pmid= 14584072 |doi= 10.1002/cncr.11753
*cite journal | author=Suzuki M, Kobayashi H, Kanayama N, "et al." |title=Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14899–908 |year= 2004 |pmid= 14747469 |doi= 10.1074/jbc.M313130200
*cite journal | author=Hung RJ, Hsu IaW, Dreiling JL, "et al." |title=Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts. |journal=Am. J. Physiol., Cell Physiol. |volume=286 |issue= 5 |pages= C1159–69 |year= 2004 |pmid= 15075215 |doi= 10.1152/ajpcell.00400.2003
*cite journal | author=Sun LF, Zheng S, Shi Y, "et al." |title= [SNC19/ST14 gene transfection and expression influence the biological behavior of colorectal cancer cells] |journal=Zhonghua Yi Xue Za Zhi |volume=84 |issue= 10 |pages= 843–8 |year= 2004 |pmid= 15200890 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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