PLA2G7

Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma), also known as PLA2G7, is a human gene.cite web | title = Entrez Gene: PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7941| accessdate = ]

PBB_Summary
section_title =
summary_text = The PLA2G7 gene encodes platelet-activating factor (PAF) acetylhydrolase (EC 3.1.1.47), a secreted enzyme that catalyzes the degradation of PAF to inactive products by hydrolysis of the acetyl group at the sn-2 position, producing the biologically inactive products LYSO-PAF and acetate. [supplied by OMIM] cite web | title = Entrez Gene: PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7941| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schröder HC, Perovic S, Kavsan V, "et al." |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. |journal=Neurotoxicology |volume=19 |issue= 4-5 |pages= 683–8 |year= 1998 |pmid= 9745929 |doi=
*cite journal | author=Feng Y, Walsh CA |title=Protein-protein interactions, cytoskeletal regulation and neuronal migration. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 6 |pages= 408–16 |year= 2001 |pmid= 11389474 |doi= 10.1038/35077559
*cite journal | author=Tjoelker LW, Eberhardt C, Unger J, "et al." |title=Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25481–7 |year= 1995 |pmid= 7592717 |doi=
*cite journal | author=Tjoelker LW, Wilder C, Eberhardt C, "et al." |title=Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. |journal=Nature |volume=374 |issue= 6522 |pages= 549–53 |year= 1995 |pmid= 7700381 |doi= 10.1038/374549a0
*cite journal | author=Tew DG, Southan C, Rice SQ, "et al." |title=Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=16 |issue= 4 |pages= 591–9 |year= 1996 |pmid= 8624782 |doi=
*cite journal | author=Stafforini DM, Satoh K, Atkinson DL, "et al." |title=Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase. |journal=J. Clin. Invest. |volume=97 |issue= 12 |pages= 2784–91 |year= 1996 |pmid= 8675689 |doi=
*cite journal | author=Yamada Y, Yokota M |title=Loss of activity of plasma platelet-activating factor acetylhydrolase due to a novel Gln281-->Arg mutation. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 3 |pages= 772–5 |year= 1997 |pmid= 9245731 |doi= 10.1006/bbrc.1997.7047
*cite journal | author=Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, "et al." |title=HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=16 |issue= 1 |pages= 1–9 |year= 1997 |pmid= 9377118 |doi=
*cite journal | author=Sapir T, Elbaum M, Reiner O |title=Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. |journal=EMBO J. |volume=16 |issue= 23 |pages= 6977–84 |year= 1998 |pmid= 9384577 |doi= 10.1093/emboj/16.23.6977
*cite journal | author=Hiramoto M, Yoshida H, Imaizumi T, "et al." |title=A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->Phe) is a genetic risk factor for stroke. |journal=Stroke |volume=28 |issue= 12 |pages= 2417–20 |year= 1998 |pmid= 9412624 |doi=
*cite journal | author=Yamada Y, Ichihara S, Fujimura T, Yokota M |title=Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men. |journal=Metab. Clin. Exp. |volume=47 |issue= 2 |pages= 177–81 |year= 1998 |pmid= 9472966 |doi=
*cite journal | author=Yoshida H, Imaizumi T, Fujimoto K, "et al." |title=A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage but not for hypertension. |journal=Thromb. Haemost. |volume=80 |issue= 3 |pages= 372–5 |year= 1998 |pmid= 9759612 |doi=
*cite journal | author=Lecointe N, Meerabux J, Ebihara M, "et al." |title=Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma. |journal=Oncogene |volume=18 |issue= 18 |pages= 2852–9 |year= 1999 |pmid= 10362256 |doi= 10.1038/sj.onc.1202645
*cite journal | author=Kruse S, Mao XQ, Heinzmann A, "et al." |title=The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. |journal=Am. J. Hum. Genet. |volume=66 |issue= 5 |pages= 1522–30 |year= 2000 |pmid= 10733466 |doi=
*cite journal | author=Howard KM, Olson MS |title=The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19891–6 |year= 2000 |pmid= 10748027 |doi= 10.1074/jbc.M001462200
*cite journal | author=Min JH, Wilder C, Aoki J, "et al." |title=Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. |journal=Biochemistry |volume=40 |issue= 15 |pages= 4539–49 |year= 2001 |pmid= 11294621 |doi=
*cite journal | author=Quarck R, De Geest B, Stengel D, "et al." |title=Adenovirus-mediated gene transfer of human platelet-activating factor-acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice. |journal=Circulation |volume=103 |issue= 20 |pages= 2495–500 |year= 2001 |pmid= 11369691 |doi=
*cite journal | author=Unno N, Nakamura T, Mitsuoka H, "et al." |title=Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. |journal=Ann. Surg. |volume=235 |issue= 2 |pages= 297–302 |year= 2002 |pmid= 11807372 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes