UBTF

Upstream binding transcription factor, RNA polymerase I, also known as UBTF, is a human gene.cite web | title = Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7343| accessdate = ]

PBB_Summary
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summary_text = Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990). [supplied by OMIM] cite web | title = Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7343| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chan EK, Imai H, Hamel JC, Tan EM |title=Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor. |journal=J. Exp. Med. |volume=174 |issue= 5 |pages= 1239–44 |year= 1991 |pmid= 1940801 |doi=
*cite journal | author=Jantzen HM, Admon A, Bell SP, Tjian R |title=Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. |journal=Nature |volume=344 |issue= 6269 |pages= 830–6 |year= 1990 |pmid= 2330041 |doi= 10.1038/344830a0
*cite journal | author=Bell SP, Learned RM, Jantzen HM, Tjian R |title=Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. |journal=Science |volume=241 |issue= 4870 |pages= 1192–7 |year= 1988 |pmid= 3413483 |doi=
*cite journal | author=Voit R, Kuhn A, Sander EE, Grummt I |title=Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF. |journal=Nucleic Acids Res. |volume=23 |issue= 14 |pages= 2593–9 |year= 1995 |pmid= 7651819 |doi=
*cite journal | author=Hempel WM, Cavanaugh AH, Hannan RD, "et al." |title=The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor. |journal=Mol. Cell. Biol. |volume=16 |issue= 2 |pages= 557–63 |year= 1996 |pmid= 8552083 |doi=
*cite journal | author=Hanada K, Song CZ, Yamamoto K, "et al." |title=RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. |journal=EMBO J. |volume=15 |issue= 9 |pages= 2217–26 |year= 1996 |pmid= 8641287 |doi=
*cite journal | author=Pluta AF, Earnshaw WC |title=Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18767–74 |year= 1996 |pmid= 8702533 |doi=
*cite journal | author=Matera AG, Wu W, Imai H, "et al." |title=Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping. |journal=Genomics |volume=41 |issue= 1 |pages= 135–8 |year= 1997 |pmid= 9126496 |doi= 10.1006/geno.1997.4647
*cite journal | author=Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB |title=ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes. |journal=Chromosoma |volume=106 |issue= 8 |pages= 493–502 |year= 1998 |pmid= 9426281 |doi=
*cite journal | author=Voit R, Hoffmann M, Grummt I |title=Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1891–9 |year= 1999 |pmid= 10202152 |doi= 10.1093/emboj/18.7.1891
*cite journal | author=Liu CJ, Wang H, Lengyel P |title=The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription. |journal=EMBO J. |volume=18 |issue= 10 |pages= 2845–54 |year= 1999 |pmid= 10329630 |doi= 10.1093/emboj/18.10.2845
*cite journal | author=Hannan KM, Hannan RD, Smith SD, "et al." |title=Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. |journal=Oncogene |volume=19 |issue= 43 |pages= 4988–99 |year= 2000 |pmid= 11042686 |doi= 10.1038/sj.onc.1203875
*cite journal | author=Kalousek I, Krízková P |title=Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=46 |issue= 7 |pages= 1163–71 |year= 2001 |pmid= 11075946 |doi=
*cite journal | author=Pelletier G, Stefanovsky VY, Faubladier M, "et al." |title=Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. |journal=Mol. Cell |volume=6 |issue= 5 |pages= 1059–66 |year= 2002 |pmid= 11106745 |doi=
*cite journal | author=Miller G, Panov KI, Friedrich JK, "et al." |title=hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. |journal=EMBO J. |volume=20 |issue= 6 |pages= 1373–82 |year= 2001 |pmid= 11250903 |doi= 10.1093/emboj/20.6.1373
*cite journal | author=Seither P, Iben S, Thiry M, Grummt I |title=PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I. |journal=Biol. Chem. |volume=382 |issue= 8 |pages= 1163–70 |year= 2002 |pmid= 11592397 |doi=
*cite journal | author=Voit R, Grummt I |title=Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 24 |pages= 13631–6 |year= 2002 |pmid= 11698641 |doi= 10.1073/pnas.231071698
*cite journal | author=Stefanovsky VY, Pelletier G, Hannan R, "et al." |title=An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF. |journal=Mol. Cell |volume=8 |issue= 5 |pages= 1063–73 |year= 2002 |pmid= 11741541 |doi=
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Dühr S, Torres-Montaner A, Astola A, "et al." |title=Molecular analysis of the 5' region of human ribosomal transcription factor UBF. |journal=DNA Seq. |volume=12 |issue= 4 |pages= 267–72 |year= 2002 |pmid= 11916260 |doi=

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