FASN

Fatty acid synthase, also known as FASN, is a human gene.cite web | title = Entrez Gene: FASN fatty acid synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2194| accessdate = ]

PBB_Summary
section_title =
summary_text = The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.cite web | title = Entrez Gene: FASN fatty acid synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2194| accessdate = ]

ee also

* Fatty acid synthase

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wakil SJ |title=Fatty acid synthase, a proficient multifunctional enzyme. |journal=Biochemistry |volume=28 |issue= 11 |pages= 4523–30 |year= 1989 |pmid= 2669958 |doi=
*cite journal | author=Baron A, Migita T, Tang D, Loda M |title=Fatty acid synthase: a metabolic oncogene in prostate cancer? |journal=J. Cell. Biochem. |volume=91 |issue= 1 |pages= 47–53 |year= 2004 |pmid= 14689581 |doi= 10.1002/jcb.10708
*cite journal | author=Lejin D |title= [Viscosimetry in clinical practice] |journal=Med. Pregl. |volume=30 |issue= 9-10 |pages= 477–82 |year= 1978 |pmid= 600212 |doi=
*cite journal | author=Wronkowski Z |title= [Cancer diagnosis of the respiratory system] |journal=Pielȩgniarka i połozna |volume= |issue= 12 |pages= 7–8 |year= 1976 |pmid= 1044453 |doi=
*cite journal | author=Jayakumar A, Tai MH, Huang WY, "et al." |title=Human fatty acid synthase: properties and molecular cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 19 |pages= 8695–9 |year= 1995 |pmid= 7567999 |doi=
*cite journal | author=Semenkovich CF, Coleman T, Fiedorek FT |title=Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation. |journal=J. Lipid Res. |volume=36 |issue= 7 |pages= 1507–21 |year= 1995 |pmid= 7595075 |doi=
*cite journal | author=Jayakumar A, Chirala SS, Chinault AC, "et al." |title=Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene. |journal=Genomics |volume=23 |issue= 2 |pages= 420–4 |year= 1995 |pmid= 7835891 |doi= 10.1006/geno.1994.1518
*cite journal | author=Kuhajda FP, Jenner K, Wood FD, "et al." |title=Fatty acid synthesis: a potential selective target for antineoplastic therapy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6379–83 |year= 1994 |pmid= 8022791 |doi=
*cite journal | author=Hsu MH, Chirala SS, Wakil SJ |title=Human fatty-acid synthase gene. Evidence for the presence of two promoters and their functional interaction. |journal=J. Biol. Chem. |volume=271 |issue= 23 |pages= 13584–92 |year= 1996 |pmid= 8662758 |doi=
*cite journal | author=Pizer ES, Kurman RJ, Pasternack GR, Kuhajda FP |title=Expression of fatty acid synthase is closely linked to proliferation and stromal decidualization in cycling endometrium. |journal=Int. J. Gynecol. Pathol. |volume=16 |issue= 1 |pages= 45–51 |year= 1997 |pmid= 8986532 |doi=
*cite journal | author=Jayakumar A, Chirala SS, Wakil SJ |title=Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 23 |pages= 12326–30 |year= 1997 |pmid= 9356448 |doi=
*cite journal | author=Kusakabe T, Maeda M, Hoshi N, "et al." |title=Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells. |journal=J. Histochem. Cytochem. |volume=48 |issue= 5 |pages= 613–22 |year= 2000 |pmid= 10769045 |doi=
*cite journal | author=Ye Q, Chung LW, Li S, Zhau HE |title=Identification of a novel FAS/ER-alpha fusion transcript expressed in human cancer cells. |journal=Biochim. Biophys. Acta |volume=1493 |issue= 3 |pages= 373–7 |year= 2000 |pmid= 11018265 |doi=
*cite journal | author=Rochat-Steiner V, Becker K, Micheau O, "et al." |title=FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation. |journal=J. Exp. Med. |volume=192 |issue= 8 |pages= 1165–74 |year= 2000 |pmid= 11034606 |doi=
*cite journal | author=Chirala SS, Jayakumar A, Gu ZW, Wakil SJ |title=Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 6 |pages= 3104–8 |year= 2001 |pmid= 11248039 |doi= 10.1073/pnas.051635998
*cite journal | author=Brink J, Ludtke SJ, Yang CY, "et al." |title=Quaternary structure of human fatty acid synthase by electron cryomicroscopy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 138–43 |year= 2002 |pmid= 11756679 |doi= 10.1073/pnas.012589499
*cite journal | author=Joseph SB, Laffitte BA, Patel PH, "et al." |title=Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 11019–25 |year= 2002 |pmid= 11790787 |doi= 10.1074/jbc.M111041200
*cite journal | author=Ming D, Kong Y, Wakil SJ, "et al." |title=Domain movements in human fatty acid synthase by quantized elastic deformational model. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 7895–9 |year= 2002 |pmid= 12060737 |doi= 10.1073/pnas.112222299
*cite journal | author=Field FJ, Born E, Murthy S, Mathur SN |title=Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport. |journal=Biochem. J. |volume=368 |issue= Pt 3 |pages= 855–64 |year= 2003 |pmid= 12213084 |doi= 10.1042/BJ20020731

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