- PROCR
Protein C receptor, endothelial (EPCR), also known as PROCR, is a human
gene .cite web | title = Entrez Gene: PROCR protein C receptor, endothelial (EPCR)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10544| accessdate = ]PROCR has also recently been designated CD201 (
cluster of differentiation 201).PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.cite web | title = Entrez Gene: PROCR protein C receptor, endothelial (EPCR)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10544| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Esmon CT |title=Coagulation and inflammation. |journal=J. Endotoxin Res. |volume=9 |issue= 3 |pages= 192–8 |year= 2004 |pmid= 12831462 |doi= 10.1179/096805103125001603
*cite journal | author=Ruf W, Dorfleutner A, Riewald M |title=Specificity of coagulation factor signaling. |journal=J. Thromb. Haemost. |volume=1 |issue= 7 |pages= 1495–503 |year= 2003 |pmid= 12871285 |doi=
*cite journal | author=Van de Wouwer M, Collen D, Conway EM |title=Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 8 |pages= 1374–83 |year= 2005 |pmid= 15178554 |doi= 10.1161/01.ATV.0000134298.25489.92
*cite journal | author=Medina P, Navarro S, Estellés A, España F |title=Polymorphisms in the endothelial protein C receptor gene and thrombophilia. |journal=Thromb. Haemost. |volume=98 |issue= 3 |pages= 564–9 |year= 2007 |pmid= 17849044 |doi=
*cite journal | author=Raheja KK |title=Nursing in transition. |journal=Nursing forum |volume=15 |issue= 4 |pages= 413–7 |year= 1977 |pmid= 1051893 |doi=
*cite journal | author=Fukudome K, Esmon CT |title=Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. |journal=J. Biol. Chem. |volume=269 |issue= 42 |pages= 26486–91 |year= 1994 |pmid= 7929370 |doi=
*cite journal | author=Laszik Z, Mitro A, Taylor FB, "et al." |title=Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway. |journal=Circulation |volume=96 |issue= 10 |pages= 3633–40 |year= 1998 |pmid= 9396465 |doi=
*cite journal | author=Ye X, Fukudome K, Tsuneyoshi N, "et al." |title=The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries. |journal=Biochem. Biophys. Res. Commun. |volume=259 |issue= 3 |pages= 671–7 |year= 1999 |pmid= 10364477 |doi= 10.1006/bbrc.1999.0846
*cite journal | author=Simmonds RE, Lane DA |title=Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains. |journal=Blood |volume=94 |issue= 2 |pages= 632–41 |year= 1999 |pmid= 10397730 |doi=
*cite journal | author=Rothbarth K, Dabaghian AR, Stammer H, Werner D |title=One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR). |journal=FEBS Lett. |volume=458 |issue= 1 |pages= 77–80 |year= 1999 |pmid= 10518938 |doi=
*cite journal | author=Hayashi T, Nakamura H, Okada A, "et al." |title=Organization and chromosomal localization of the human endothelial protein C receptor gene. |journal=Gene |volume=238 |issue= 2 |pages= 367–73 |year= 1999 |pmid= 10570964 |doi=
*cite journal | author=Liaw PC, Neuenschwander PF, Smirnov MD, Esmon CT |title=Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5447–52 |year= 2000 |pmid= 10681521 |doi=
*cite journal | author=Xu J, Qu D, Esmon NL, Esmon CT |title=Metalloproteolytic release of endothelial cell protein C receptor. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 6038–44 |year= 2000 |pmid= 10681599 |doi=
*cite journal | author=Liaw PC, Mather T, Oganesyan N, "et al." |title=Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8364–70 |year= 2001 |pmid= 11099506 |doi= 10.1074/jbc.M010572200
*cite journal | author=Biguzzi E, Merati G, Liaw PC, "et al." |title=A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function. |journal=Thromb. Haemost. |volume=86 |issue= 4 |pages= 945–8 |year= 2002 |pmid= 11686350 |doi=
*cite journal | author=Galligan L, Livingstone W, Volkov Y, "et al." |title=Characterization of protein C receptor expression in monocytes. |journal=Br. J. Haematol. |volume=115 |issue= 2 |pages= 408–14 |year= 2001 |pmid= 11703343 |doi=
*cite journal | author=von Depka M, Czwalinna A, Eisert R, "et al." |title=Prevalence of a 23bp insertion in exon 3 of the endothelial cell protein C receptor gene in venous thrombophilia. |journal=Thromb. Haemost. |volume=86 |issue= 6 |pages= 1360–2 |year= 2002 |pmid= 11776299 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Oganesyan V, Oganesyan N, Terzyan S, "et al." |title=The crystal structure of the endothelial protein C receptor and a bound phospholipid. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24851–4 |year= 2002 |pmid= 12034704 |doi= 10.1074/jbc.C200163200
*cite journal | author=Riewald M, Petrovan RJ, Donner A, "et al." |title=Activation of endothelial cell protease activated receptor 1 by the protein C pathway. |journal=Science |volume=296 |issue= 5574 |pages= 1880–2 |year= 2002 |pmid= 12052963 |doi= 10.1126/science.1071699PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
Wikimedia Foundation. 2010.
