HNRPD

Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa), also known as HNRPD, is a human gene.cite web | title = Entrez Gene: HNRPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3184| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.cite web | title = Entrez Gene: HNRPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3184| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tay N, Chan SH, Ren EC |title=Identification and cloning of a novel heterogeneous nuclear ribonucleoprotein C-like protein that functions as a transcriptional activator of the hepatitis B virus enhancer II. |journal=J. Virol. |volume=66 |issue= 12 |pages= 6841–8 |year= 1992 |pmid= 1433497 |doi=
*cite journal | author=Lahiri DK, Thomas JO |title=A cDNA clone of the hnRNP C proteins and its homology with the single-stranded DNA binding protein UP2. |journal=Nucleic Acids Res. |volume=14 |issue= 10 |pages= 4077–94 |year= 1986 |pmid= 3754960 |doi=
*cite journal | author=Kajita Y, Nakayama J, Aizawa M, Ishikawa F |title=The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family. |journal=J. Biol. Chem. |volume=270 |issue= 38 |pages= 22167–75 |year= 1995 |pmid= 7673195 |doi=
*cite journal | author=Zhang W, Wagner BJ, Ehrenman K, "et al." |title=Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7652–65 |year= 1994 |pmid= 8246982 |doi=
*cite journal | author=Wagner BJ, Long L, Rao PN, "et al." |title=Localization and physical mapping of genes encoding the A+U-rich element RNA-binding protein AUF1 to human chromosomes 4 and X. |journal=Genomics |volume=34 |issue= 2 |pages= 219–22 |year= 1997 |pmid= 8661052 |doi= 10.1006/geno.1996.0269
*cite journal | author=Kiledjian M, DeMaria CT, Brewer G, Novick K |title=Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex. |journal=Mol. Cell. Biol. |volume=17 |issue= 8 |pages= 4870–6 |year= 1997 |pmid= 9234743 |doi=
*cite journal | author=Wagner BJ, DeMaria CT, Sun Y, "et al." |title=Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. |journal=Genomics |volume=48 |issue= 2 |pages= 195–202 |year= 1998 |pmid= 9521873 |doi= 10.1006/geno.1997.5142
*cite journal | author=Dempsey LA, Li MJ, DePace A, "et al." |title=The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. |journal=Genomics |volume=49 |issue= 3 |pages= 378–84 |year= 1998 |pmid= 9615222 |doi= 10.1006/geno.1998.5237
*cite journal | author=Siomi MC, Fromont M, Rain JC, "et al." |title=Functional conservation of the transportin nuclear import pathway in divergent organisms. |journal=Mol. Cell. Biol. |volume=18 |issue= 7 |pages= 4141–8 |year= 1998 |pmid= 9632798 |doi=
*cite journal | author=Tolnay M, Vereshchagina LA, Tsokos GC |title=Heterogeneous nuclear ribonucleoprotein D0B is a sequence-specific DNA-binding protein. |journal=Biochem. J. |volume=338 ( Pt 2) |issue= |pages= 417–25 |year= 1999 |pmid= 10024518 |doi=
*cite journal | author=Nagata T, Kurihara Y, Matsuda G, "et al." |title=Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0. |journal=J. Mol. Biol. |volume=287 |issue= 2 |pages= 221–37 |year= 1999 |pmid= 10080887 |doi=
*cite journal | author=Laroia G, Cuesta R, Brewer G, Schneider RJ |title=Control of mRNA decay by heat shock-ubiquitin-proteasome pathway. |journal=Science |volume=284 |issue= 5413 |pages= 499–502 |year= 1999 |pmid= 10205060 |doi=
*cite journal | author=Blaxall BC, Dwyer-Nield LD, Bauer AK, "et al." |title=Differential expression and localization of the mRNA binding proteins, AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue. |journal=Mol. Carcinog. |volume=28 |issue= 2 |pages= 76–83 |year= 2000 |pmid= 10900464 |doi=
*cite journal | author=Arao Y, Kuriyama R, Kayama F, Kato S |title=A nuclear matrix-associated factor, SAF-B, interacts with specific isoforms of AUF1/hnRNP D. |journal=Arch. Biochem. Biophys. |volume=380 |issue= 2 |pages= 228–36 |year= 2000 |pmid= 10933876 |doi= 10.1006/abbi.2000.1938
*cite journal | author=Grosset C, Chen CY, Xu N, "et al." |title=A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. |journal=Cell |volume=103 |issue= 1 |pages= 29–40 |year= 2000 |pmid= 11051545 |doi=
*cite journal | author=Katahira M, Miyanoiri Y, Enokizono Y, "et al." |title=Structure of the C-terminal RNA-binding domain of hnRNP D0 (AUF1), its interactions with RNA and DNA, and change in backbone dynamics upon complex formation with DNA. |journal=J. Mol. Biol. |volume=311 |issue= 5 |pages= 973–88 |year= 2001 |pmid= 11531333 |doi= 10.1006/jmbi.2001.4862
*cite journal | author=Lapucci A, Donnini M, Papucci L, "et al." |title=AUF1 Is a bcl-2 A + U-rich element-binding protein involved in bcl-2 mRNA destabilization during apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 16139–46 |year= 2002 |pmid= 11856759 |doi= 10.1074/jbc.M201377200
*cite journal | author=Tolnay M, Juang YT, Tsokos GC |title=Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion. |journal=Biochem. J. |volume=363 |issue= Pt 1 |pages= 127–36 |year= 2002 |pmid= 11903055 |doi=
*cite journal | author=Pioli PA, Hamilton BJ, Connolly JE, "et al." |title=Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35738–45 |year= 2002 |pmid= 12107167 |doi= 10.1074/jbc.M204002200
*cite journal | author=Shchors K, Yehiely F, Kular RK, "et al." |title=Cell death inhibiting RNA (CDIR) derived from a 3'-untranslated region binds AUF1 and heat shock protein 27. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47061–72 |year= 2003 |pmid= 12356764 |doi= 10.1074/jbc.M202272200

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