SLPI

SLPI

Secretory leukocyte peptidase inhibitor, also known as SLPI, is a human gene.cite web | title = Entrez Gene: SLPI secretory leukocyte peptidase inhibitor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6590| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity.cite web | title = Entrez Gene: SLPI secretory leukocyte peptidase inhibitor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6590| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Fritz H |title=Human mucus proteinase inhibitor (human MPI). Human seminal inhibitor I (HUSI-I), antileukoprotease (ALP), secretory leukocyte protease inhibitor (SLPI). |journal=Biol. Chem. Hoppe-Seyler |volume=369 Suppl |issue= |pages= 79–82 |year= 1989 |pmid= 3060147 |doi=
*cite journal | author=Sallenave JM |title=The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease. |journal=Respir. Res. |volume=1 |issue= 2 |pages= 87–92 |year= 2003 |pmid= 11667971 |doi=
*cite journal | author=Rogaev EI, Keryanov SA, Malyako YK |title=Dinucleotide repeat polymorphisms at the P1, HBE1 and MYH7 loci. |journal=Hum. Mol. Genet. |volume=1 |issue= 4 |pages= 285 |year= 1993 |pmid= 1363870 |doi=
*cite journal | author=Abe T, Kobayashi N, Yoshimura K, "et al." |title=Expression of the secretory leukoprotease inhibitor gene in epithelial cells. |journal=J. Clin. Invest. |volume=87 |issue= 6 |pages= 2207–15 |year= 1991 |pmid= 1674946 |doi=
*cite journal | author=Sallenave JM, Ryle AP |title=Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor. |journal=Biol. Chem. Hoppe-Seyler |volume=372 |issue= 1 |pages= 13–21 |year= 1991 |pmid= 2039600 |doi=
*cite journal | author=Eisenberg SP, Hale KK, Heimdal P, Thompson RC |title=Location of the protease-inhibitory region of secretory leukocyte protease inhibitor. |journal=J. Biol. Chem. |volume=265 |issue= 14 |pages= 7976–81 |year= 1990 |pmid= 2110563 |doi=
*cite journal | author=Grütter MG, Fendrich G, Huber R, Bode W |title=The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin. |journal=EMBO J. |volume=7 |issue= 2 |pages= 345–51 |year= 1988 |pmid= 3366116 |doi=
*cite journal | author=Thompson RC, Ohlsson K |title=Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 18 |pages= 6692–6 |year= 1986 |pmid= 3462719 |doi=
*cite journal | author=Seemüller U, Arnhold M, Fritz H, "et al." |title=The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red Sea turtle proteinase inhibitor. |journal=FEBS Lett. |volume=199 |issue= 1 |pages= 43–8 |year= 1986 |pmid= 3485543 |doi=
*cite journal | author=Heinzel R, Appelhans H, Gassen G, "et al." |title=Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus. |journal=Eur. J. Biochem. |volume=160 |issue= 1 |pages= 61–7 |year= 1986 |pmid= 3533531 |doi=
*cite journal | author=Stetler G, Brewer MT, Thompson RC |title=Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases. |journal=Nucleic Acids Res. |volume=14 |issue= 20 |pages= 7883–96 |year= 1986 |pmid= 3640338 |doi=
*cite journal | author=Westin U, Fryksmark U, Polling A, Ohlsson K |title=Localisation of secretory leucocyte proteinase inhibitor mRNA in nasal mucosa. |journal=Acta Otolaryngol. |volume=114 |issue= 2 |pages= 199–202 |year= 1994 |pmid= 7515550 |doi=
*cite journal | author=Ohlsson K, Bjartell A, Lilja H |title=Secretory leucocyte protease inhibitor in the male genital tract: PSA-induced proteolytic processing in human semen and tissue localization. |journal=J. Androl. |volume=16 |issue= 1 |pages= 64–74 |year= 1995 |pmid= 7539415 |doi=
*cite journal | author=Belorgey D, Dirrig S, Amouric M, "et al." |title=Inhibition of human pancreatic proteinases by mucus proteinase inhibitor, eglin c and aprotinin. |journal=Biochem. J. |volume=313 ( Pt 2) |issue= |pages= 555–60 |year= 1996 |pmid= 8573092 |doi=
*cite journal | author=Kikuchi T, Abe T, Hoshi S, "et al." |title=Structure of the murine secretory leukoprotease inhibitor (Slpi) gene and chromosomal localization of the human and murine SLPI genes. |journal=Am. J. Respir. Cell Mol. Biol. |volume=19 |issue= 6 |pages= 875–80 |year= 1999 |pmid= 9843921 |doi=
*cite journal | author=Westin U, Polling A, Ljungkrantz I, Ohlsson K |title=Identification of SLPI (secretory leukocyte protease inhibitor) in human mast cells using immunohistochemistry and in situ hybridisation. |journal=Biol. Chem. |volume=380 |issue= 4 |pages= 489–93 |year= 1999 |pmid= 10355635 |doi=
*cite journal | author=Mulligan MS, Lentsch AB, Huber-Lang M, "et al." |title=Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor. |journal=Am. J. Pathol. |volume=156 |issue= 3 |pages= 1033–9 |year= 2000 |pmid= 10702419 |doi=
*cite journal | author=Nyström M, Bergenfeldt M, Ljungcrantz I, "et al." |title=Production of secretory leucocyte protease inhibitor (SLPI) in human pancreatic beta-cells. |journal=Mediators Inflamm. |volume=8 |issue= 3 |pages= 147–51 |year= 2000 |pmid= 10704052 |doi=
*cite journal | author=Si-Tahar M, Merlin D, Sitaraman S, Madara JL |title=Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells. |journal=Gastroenterology |volume=118 |issue= 6 |pages= 1061–71 |year= 2000 |pmid= 10833481 |doi=

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