FGF7

FGF7

Fibroblast growth factor 7 (keratinocyte growth factor), also known as FGF7, is a human gene.cite web | title = Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2252| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.cite web | title = Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2252| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Beer HD, Gassmann MG, Munz B, "et al." |title=Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair. |journal=J. Investig. Dermatol. Symp. Proc. |volume=5 |issue= 1 |pages= 34–9 |year= 2001 |pmid= 11147673 |doi= 10.1046/j.1087-0024.2000.00009.x
*cite journal | author=Ware LB, Matthay MA |title=Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=282 |issue= 5 |pages= L924–40 |year= 2002 |pmid= 11943656 |doi= 10.1152/ajplung.00439.2001
*cite journal | author=Finch PW, Rubin JS |title=Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. |journal=Adv. Cancer Res. |volume=91 |issue= |pages= 69–136 |year= 2004 |pmid= 15327889 |doi= 10.1016/S0065-230X(04)91003-2
*cite journal | author=Ishibashi T, Bottaro DP, Chan A, "et al." |title=Expression cloning of a human dual-specificity phosphatase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 24 |pages= 12170–4 |year= 1993 |pmid= 1281549 |doi=
*cite journal | author=Kelley MJ, Pech M, Seuanez HN, "et al." |title=Emergence of the keratinocyte growth factor multigene family during the great ape radiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 19 |pages= 9287–91 |year= 1992 |pmid= 1409637 |doi=
*cite journal | author=Aaronson SA, Bottaro DP, Miki T, "et al." |title=Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. |journal=Ann. N. Y. Acad. Sci. |volume=638 |issue= |pages= 62–77 |year= 1992 |pmid= 1664700 |doi=
*cite journal | author=Finch PW, Rubin JS, Miki T, "et al." |title=Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. |journal=Science |volume=245 |issue= 4919 |pages= 752–5 |year= 1989 |pmid= 2475908 |doi=
*cite journal | author=Rubin JS, Osada H, Finch PW, "et al." |title=Purification and characterization of a newly identified growth factor specific for epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 3 |pages= 802–6 |year= 1989 |pmid= 2915979 |doi=
*cite journal | author=Ron D, Reich R, Chedid M, "et al." |title=Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor. |journal=J. Biol. Chem. |volume=268 |issue= 8 |pages= 5388–94 |year= 1993 |pmid= 7680645 |doi=
*cite journal | author=Yan G, Fukabori Y, McBride G, "et al." |title=Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. |journal=Mol. Cell. Biol. |volume=13 |issue= 8 |pages= 4513–22 |year= 1993 |pmid= 7687739 |doi=
*cite journal | author=Mattei MG, deLapeyrière O, Bresnick J, "et al." |title=Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively. |journal=Mamm. Genome |volume=6 |issue= 3 |pages= 196–7 |year= 1995 |pmid= 7749227 |doi=
*cite journal | author=Werner S, Smola H, Liao X, "et al." |title=The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. |journal=Science |volume=266 |issue= 5186 |pages= 819–22 |year= 1994 |pmid= 7973639 |doi=
*cite journal | author=Wilson SE, Walker JW, Chwang EL, He YG |title=Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea. |journal=Invest. Ophthalmol. Vis. Sci. |volume=34 |issue= 8 |pages= 2544–61 |year= 1993 |pmid= 8392040 |doi=
*cite journal | author=Guo L, Degenstein L, Fuchs E |title=Keratinocyte growth factor is required for hair development but not for wound healing. |journal=Genes Dev. |volume=10 |issue= 2 |pages= 165–75 |year= 1996 |pmid= 8566750 |doi=
*cite journal | author=Ornitz DM, Xu J, Colvin JS, "et al." |title=Receptor specificity of the fibroblast growth factor family. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15292–7 |year= 1996 |pmid= 8663044 |doi=
*cite journal | author=Post M, Souza P, Liu J, "et al." |title=Keratinocyte growth factor and its receptor are involved in regulating early lung branching. |journal=Development |volume=122 |issue= 10 |pages= 3107–15 |year= 1996 |pmid= 8898224 |doi=
*cite journal | author=Zimonjic DB, Kelley MJ, Rubin JS, "et al." |title=Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11461–5 |year= 1997 |pmid= 9326632 |doi=
*cite journal | author=Winkles JA, Alberts GF, Chedid M, "et al." |title=Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries. |journal=J. Cell. Physiol. |volume=173 |issue= 3 |pages= 380–6 |year= 1997 |pmid= 9369951 |doi= 10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G |doilabel=10.1002/(SICI)1097-4652(199712)173:3380::AID-JCP103.0.CO;2-G
*cite journal | author=Ishibashi T, Tanaka T, Nibu K, "et al." |title=Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps. |journal=Ann. Otol. Rhinol. Laryngol. |volume=107 |issue= 10 Pt 1 |pages= 885–90 |year= 1998 |pmid= 9794620 |doi=
*cite journal | author=Mongiat M, Taylor K, Otto J, "et al." |title=The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7095–100 |year= 2000 |pmid= 10702276 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Limb development — The tetrapod limb develops from a specific area of the body axis called the limb field. The position of the limb field is associated with and presumably specified by the spatial pattern of Hox gene expression along the body axis. Retinoic acid… …   Wikipedia

  • Desarrollo de las extremidades — Saltar a navegación, búsqueda Embrión humano de seis semanas …   Wikipedia Español

  • Фактор роста фибробластов — Результат анализа кристаллической структуры комплекса fgf10 fgfr2b Фактор роста фибробластов …   Википедия

  • Platelet-derived growth factor — (PDGF) Identifiers Symbol PDGF Pfam PF00341 InterPro …   Wikipedia

  • Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 …   Wikipedia

  • Nerve growth factor — (beta polypeptide) Rendering of NGF from PDB 1SG1 …   Wikipedia

  • Fibroblast growth factor — Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. The FGFs are heparin binding proteins and interactions with cell surface associated heparan sulfate… …   Wikipedia

  • Extracellular signal-regulated kinases — Main article: Mitogen activated protein kinase In molecular biology, extracellular signal regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions… …   Wikipedia

  • Cutaneous structure development — Cutaneous structures arise from the epidermis and include a variety of features such as hair, feathers, claws and nails. During embryogenesis, the epidermis splits into two layers: the periderm (which is lost) and the basal layer. The basal layer …   Wikipedia

  • Keratinocyte Growth Factor — The Keratinocyte Growth Factor (KGF) is a growth factor present in the epithelialization phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.KGF, also referred to as FGF7 is a small signaling… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”