Hydroxyethylthiazole kinase

In enzymology, a hydroxyethylthiazole kinase (EC number|2.7.1.50) is an enzyme that catalyzes the chemical reaction

:ATP + 4-methyl-5-(2-hydroxyethyl)thiazole $ightleftharpoons$ ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole

Thus, the two substrates of this enzyme are ATP and 4-methyl-5-(2-hydroxyethyl)thiazole, whereas its two products are ADP and 4-methyl-5-(2-phosphonooxyethyl)thiazole.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase. Other names in common use include hydroxyethylthiazole kinase (phosphorylating), and 4-methyl-5-(beta-hydroxyethyl)thiazole kinase. This enzyme participates in thiamine metabolism.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1C3Q, PDB link|1EKK, PDB link|1EKQ, PDB link|1ESJ, PDB link|1ESQ, and PDB link|1V8A.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-56-6."

Gene Ontology (GO) codes