3-deoxy-manno-octulosonate cytidylyltransferase

In enzymology, a 3-deoxy-manno-octulosonate cytidylyltransferase (EC number|2.7.7.38) is an enzyme that catalyzes the chemical reaction

:CTP + 3-deoxy-D-manno-octulosonate $ightleftharpoons$ diphosphate + CMP-3-deoxy-D-manno-octulosonate

Thus, the two substrates of this enzyme are CTP and 3-deoxy-D-manno-octulosonate, whereas its two products are diphosphate and CMP-3-deoxy-D-manno-octulosonate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase. Other names in common use include CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase, 2-keto-3-deoxyoctonate cytidylyltransferase, 3-Deoxy-D-manno-octulosonate cytidylyltransferase, CMP-3-deoxy-D-manno-octulosonate synthetase, CMP-KDO synthetase, CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase, and cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase. This enzyme participates in lipopolysaccharide biosynthesis.

tructural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GQ9, PDB link|1GQC, PDB link|1H6J, PDB link|1H7E, PDB link|1H7F, PDB link|1H7G, PDB link|1H7H, PDB link|1H7T, PDB link|1VH1, PDB link|1VH3, and PDB link|1VIC.

References

*

External links

::"The CAS registry number for this enzyme class is CAS registry|37278-28-7."

Gene Ontology (GO) codes