S-methyl-5'-thioadenosine phosphorylase

In enzymology, a S-methyl-5'-thioadenosine phosphorylase (EC number|2.4.2.28) is an enzyme that catalyzes the chemical reaction

:S-methyl-5'-thioadenosine + phosphate $ightleftharpoons$ adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are S-methyl-5'-thioadenosine and phosphate, whereas its two products are adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase. Other names in common use include 5'-methylthioadenosine nucleosidase, 5'-deoxy-5'-methylthioadenosine phosphorylase, MTA phosphorylase, MeSAdo phosphorylase, MeSAdo/Ado phosphorylase, methylthioadenosine phosphorylase, methylthioadenosine nucleoside phosphorylase, 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase, and S-methyl-5-thioadenosine phosphorylase. This enzyme participates in methionine metabolism.

tructural studies

As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1CB0, PDB link|1CG6, PDB link|1JDS, PDB link|1JDT, PDB link|1JDU, PDB link|1JDV, PDB link|1JDZ, PDB link|1JE0, PDB link|1JE1, PDB link|1JP7, PDB link|1JPV, PDB link|1K27, PDB link|1ODI, PDB link|1ODJ, PDB link|1ODK, PDB link|1SD1, PDB link|1SD2, PDB link|1V4N, PDB link|1WTA, and PDB link|2A8Y.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|61970-06-7."

Gene Ontology (GO) codes