Carboxylesterase family

Carboxylesterase, type B is a family of evolutionarily related proteins.

Higher eukaryotes have many distinct esterases. Among the different types are those which act on carboxylic esters (EC number|3.1.1). Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicatescite journal |author=Myers M, Richmond RC, Oakeshott JG |title=On the origins of esterases |journal=Mol. Biol. Evol. |volume=5 |issue=2 |pages=113–119 |year=1988 |pmid=3163407] cite journal |author=Chatonnet A, Krejci E, Duval N, Vincens P, Massoulie J |title=Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue=15 |pages=6647–6651 |year=1991 |pmid=1862088 |doi=10.1073/pnas.88.15.6647] cite journal |author=Sussman JL, Cygler M, Harel M, Silman I, Schrag JD, Doctor BP, Gentry MK |title=Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins |journal=Protein Sci. |volume=2 |issue=3 |pages=366–382 |year=1993 |pmid=8453375] that the majority are evolutionarily related. As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.

ubfamilies

*Neuroligin InterPro|IPR000460
*Cholinesterase InterPro|IPR000997

Human proteins containing this domain

ACHE; ARACHE; BCHE; CEL; CES; CES1; CES2; CES3;
CES4; CES7; NLGN1; NLGN2; NLGN3; NLGN4X; NLGN4Y; TG;

References

External links

* [http://www.expasy.org/cgi-bin/nicedoc.pl?PDOC00112 Carboxylesterases type-B] in PROSITE

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Carboxylesterase family

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