Lactosylceramide 4-alpha-galactosyltransferase

Lactosylceramide 4-alpha-galactosyltransferase

In enzymology, a lactosylceramide 4-alpha-galactosyltransferase (EC number|2.4.1.228) is an enzyme that catalyzes the chemical reaction

:UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosylceramide ightleftharpoons UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D- glucosylceramide

Thus, the two substrates of this enzyme are UDP-galactose and beta-D-galactosyl-(1->4)-D-glucosylceramide, whereas its 3 products are UDP, alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-, and glucosylceramide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase. Other names in common use include Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase, globotriaosylceramide/CD77 synthase, and histo-blood group Pk UDP-galactose. This enzyme participates in glycosphingolipid biosynthesis - globoseries and glycan structures - biosynthesis 2.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|52725-57-2."

Gene Ontology (GO) codes


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  • A4GALT — Alpha 1,4 galactosyltransferase (globotriaosylceramide synthase), also known as A4GALT, is a human gene.cite web | title = Entrez Gene: A4GALT alpha 1,4 galactosyltransferase (globotriaosylceramide synthase)| url =… …   Wikipedia

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