- Lactosylceramide 4-alpha-galactosyltransferase
enzymology, a lactosylceramide 4-alpha-galactosyltransferase (EC number|220.127.116.11) is an enzymethat catalyzes the chemical reaction
:UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosylceramide UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D- glucosylceramide
Thus, the two substrates of this enzyme are
UDP-galactoseand beta-D-galactosyl-(1->4)-D-glucosylceramide, whereas its 3 products are UDP, alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-, and glucosylceramide.
This enzyme belongs to the family of
glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase. Other names in common use include Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase, globotriaosylceramide/CD77 synthase, and histo-blood group Pk UDP-galactose. This enzyme participates in glycosphingolipid biosynthesis - globoseriesand glycan structures - biosynthesis 2.
CAS registry numberfor this enzyme class is CAS registry|52725-57-2."
Gene Ontology (GO) codes
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