A4GALT

Alpha 1,4-galactosyltransferase (globotriaosylceramide synthase), also known as A4GALT, is a human gene.cite web | title = Entrez Gene: A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53947| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.cite web | title = Entrez Gene: A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53947| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Steffensen R, Carlier K, Wiels J, "et al." |title=Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16723–9 |year= 2000 |pmid= 10747952 |doi= 10.1074/jbc.M000728200
*cite journal | author=Kojima Y, Fukumoto S, Furukawa K, "et al." |title=Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15152–6 |year= 2000 |pmid= 10748143 |doi= 10.1074/jbc.M909620199
*cite journal | author=Keusch JJ, Manzella SM, Nyame KA, "et al." |title=Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25315–21 |year= 2000 |pmid= 10854428 |doi= 10.1074/jbc.M002630200
*cite journal | author=Furukawa K, Iwamura K, Uchikawa M, "et al." |title=Molecular basis for the p phenotype. Identification of distinct and multiple mutations in the alpha 1,4-galactosyltransferase gene in Swedish and Japanese individuals. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37752–6 |year= 2001 |pmid= 10993874 |doi= 10.1074/jbc.C000625200
*cite journal | author=Furukawa K, Yokoyama K, Sato T, "et al." |title=Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells: implication in the sensitivity to verotoxins. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 11247–54 |year= 2002 |pmid= 11782470 |doi= 10.1074/jbc.M109519200
*cite journal | author=Koda Y, Soejima M, Sato H, "et al." |title=Three-base deletion and one-base insertion of the alpha(1,4)galactosyltransferase gene responsible for the P phenotype. |journal=Transfusion |volume=42 |issue= 1 |pages= 48–51 |year= 2002 |pmid= 11896312 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Iwamura K, Furukawa K, Uchikawa M, "et al." |title=The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene. A clue to the solution of the P1/P2/p puzzle. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44429–38 |year= 2004 |pmid= 12888565 |doi= 10.1074/jbc.M301609200
*cite journal | author=Hellberg A, Ringressi A, Yahalom V, "et al." |title=Genetic heterogeneity at the glycosyltransferase loci underlying the GLOB blood group system and collection. |journal=Br. J. Haematol. |volume=125 |issue= 4 |pages= 528–36 |year= 2004 |pmid= 15142124 |doi= 10.1111/j.1365-2141.2004.04930.x
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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