Trypsin 1

Trypsin 1

Protease, serine, 1 (trypsin 1), also known as PRSS1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [cite web | title = Entrez Gene: PRSS1 protease, serine, 1 (trypsin 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5644| accessdate = ]

ee also

*Trypsin

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chen JM, Ferec C |title=Molecular basis of hereditary pancreatitis. |journal=Eur. J. Hum. Genet. |volume=8 |issue= 7 |pages= 473–9 |year= 2000 |pmid= 10909845 |doi= 10.1038/sj.ejhg.5200492
*cite journal | author=Chen JM, Ferec C |title=Gene conversion-like missense mutations in the human cationic trypsinogen gene and insights into the molecular evolution of the human trypsinogen family. |journal=Mol. Genet. Metab. |volume=71 |issue= 3 |pages= 463–9 |year= 2000 |pmid= 11073713 |doi= 10.1006/mgme.2000.3086
*cite journal | author=Chen JM, Montier T, Férec C |title=Molecular pathology and evolutionary and physiological implications of pancreatitis-associated cationic trypsinogen mutations. |journal=Hum. Genet. |volume=109 |issue= 3 |pages= 245–52 |year= 2001 |pmid= 11702203 |doi= 10.1007/s004390100580
*cite journal | author=Howes N, Greenhalf W, Stocken DD, Neoptolemos JP |title=Cationic trypsinogen mutations and pancreatitis. |journal=Clin. Lab. Med. |volume=25 |issue= 1 |pages= 39–59 |year= 2005 |pmid= 15749231 |doi= 10.1016/j.cll.2004.12.004
*cite journal | author=Kandula L, Whitcomb DC, Lowe ME |title=Genetic issues in pediatric pancreatitis. |journal=Current gastroenterology reports |volume=8 |issue= 3 |pages= 248–53 |year= 2006 |pmid= 16764792 |doi=10.1007/s11894-006-0083-8
*cite journal | author=Yamamoto KK, Pousette A, Chow P, "et al." |title=Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B. |journal=J. Biol. Chem. |volume=267 |issue= 4 |pages= 2575–81 |year= 1992 |pmid= 1370825 |doi=
*cite journal | author=Pollard SR, Meier W, Chow P, "et al." |title=CD4-binding regions of human immunodeficiency virus envelope glycoprotein gp120 defined by proteolytic digestion. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 24 |pages= 11320–4 |year= 1992 |pmid= 1763044 |doi=10.1073/pnas.88.24.11320
*cite journal | author=Shieh BH, Travis J |title=The reactive site of human alpha 2-antiplasmin. |journal=J. Biol. Chem. |volume=262 |issue= 13 |pages= 6055–9 |year= 1987 |pmid= 2437112 |doi=
*cite journal | author=Kimland M, Russick C, Marks WH, Borgström A |title=Immunoreactive anionic and cationic trypsin in human serum. |journal=Clin. Chim. Acta |volume=184 |issue= 1 |pages= 31–46 |year= 1990 |pmid= 2598466 |doi=10.1016/0009-8981(89)90254-4
*cite journal | author=Emi M, Nakamura Y, Ogawa M, "et al." |title=Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. |journal=Gene |volume=41 |issue= 2-3 |pages= 305–10 |year= 1986 |pmid= 3011602 |doi=10.1016/0378-1119(86)90111-3
*cite journal | author=Honey NK, Sakaguchi AY, Quinto C, "et al." |title=Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase. |journal=Somat. Cell Mol. Genet. |volume=10 |issue= 4 |pages= 369–76 |year= 1984 |pmid= 6589790 |doi=10.1007/BF01535632
*cite journal | author=Merrill GA, Butler M, Horowitz PM |title=Limited tryptic digestion near the amino terminus of bovine liver rhodanese produces active electrophoretic variants with altered refolding. |journal=J. Biol. Chem. |volume=268 |issue= 21 |pages= 15611–20 |year= 1993 |pmid= 8340386 |doi=
*cite journal | author=Rowen L, Koop BF, Hood L |title=The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. |journal=Science |volume=272 |issue= 5269 |pages= 1755–62 |year= 1996 |pmid= 8650574 |doi=10.1126/science.272.5269.1755
*cite journal | author=Gaboriaud C, Serre L, Guy-Crotte O, "et al." |title=Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151. |journal=J. Mol. Biol. |volume=259 |issue= 5 |pages= 995–1010 |year= 1996 |pmid= 8683601 |doi= 10.1006/jmbi.1996.0376
*cite journal | author=Whitcomb DC, Gorry MC, Preston RA, "et al." |title=Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. |journal=Nat. Genet. |volume=14 |issue= 2 |pages= 141–5 |year= 1996 |pmid= 8841182 |doi= 10.1038/ng1096-141
*cite journal | author=Gu M, Majerus PW |title=The properties of the protein tyrosine phosphatase PTPMEG. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27751–9 |year= 1996 |pmid= 8910369 |doi=10.1074/jbc.271.4.1825
*cite journal | author=Christensen S, Valnickova Z, Thogersen IB, "et al." |title=Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties. |journal=Biochem. J. |volume=323 ( Pt 3) |issue= |pages= 847–52 |year= 1997 |pmid= 9169621 |doi=
*cite journal | author=Gorry MC, Gabbaizedeh D, Furey W, "et al." |title=Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. |journal=Gastroenterology |volume=113 |issue= 4 |pages= 1063–8 |year= 1997 |pmid= 9322498 |doi=10.1053/gast.1997.v113.pm9322498
*cite journal | author=Dahlen JR, Foster DC, Kisiel W |title=Expression, purification, and inhibitory properties of human proteinase inhibitor. |journal=Biochemistry |volume=36 |issue= 48 |pages= 14874–82 |year= 1998 |pmid= 9402754 |doi= 10.1021/bi970977p
*cite journal | author=Teich N, Mössner J, Keim V |title=Mutations of the cationic trypsinogen in hereditary pancreatitis. |journal=Hum. Mutat. |volume=12 |issue= 1 |pages= 39–43 |year= 1998 |pmid= 9633818 |doi= 10.1002/(SICI)1098-1004(1998)12:1<39::AID-HUMU6>3.0.CO;2-P

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  • Trypsin — 1 Vorhandene Strukturdaten …   Deutsch Wikipedia

  • Trypsin — Tryp sin, n. [Gr. ? a rubbing, fr. ? to rub, grind. So called because it causes protein to break up or to fall apart.] (physiol.) A proteolytic enzyme present in the pancreatic juice. Unlike the pepsin of the gastric juice, it acts in a neutral… …   The Collaborative International Dictionary of English

  • trypsin — trypsin. См. трипсин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Trypsīn — Trypsīn, das eiweißzerlegende Ferment des Bauchspeichels (s. d.) …   Meyers Großes Konversations-Lexikon

  • Trypsin — Trypsīn, s. Pankreatin …   Kleines Konversations-Lexikon

  • Trypsin — Trypsin, den Endopeptidasen zugehörendes, Proteine zu Oligopeptiden spaltendes Verdauungsenzym der Wirbeltiere und vieler Wirbelloser, das sein pH Optimum im alkalischen Bereich (pH 7–9) hat und ausschließlich Peptidbindungen abbaut, deren… …   Deutsch wörterbuch der biologie

  • trypsin — 1876, apparently from Gk. tripsis “rubbing” + chemical suffix IN (Cf. in) (2). Said to be so called because it first was obtained by rubbing the pancreas with glycerin …   Etymology dictionary

  • trypsin — [trip′sin] n. [Ger, prob. < Gr tryein, to wear away (see TRITE) + Ger (pe)psin: see PEPSIN] 1. a proteolytic enzyme in the pancreatic juice that hydrolyzes proteins to smaller polypeptides 2. any of several similar enzymes tryptic [trip′tik]… …   English World dictionary

  • Trypsin — protein Name=protease, serine, 1 (trypsin 1) caption=Crystal structure of Trypsin width= HGNCid=9475 Symbol=PRSS1 AltSymbols=TRY1 EntrezGene=5644 OMIM=276000 RefSeq=NM 002769 UniProt=P07477 PDB= ECnumber=3.4.21.4 Chromosome=7 Arm=q Band=32… …   Wikipedia

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