Fibronectin type II domain

Pfam_box
Symbol = fn2
Name =

---

width =250
caption =Collagen-binding type II domain of seminal plasma protein PDC-109
Pfam= PF00040
InterPro= IPR000562
SMART=
PROSITE = PDOC00022
SCOP = 1pdc
TCDB =
OPM family= 123
OPM protein= 1h8p
PDB=PDB3|1ks0A:233-274 PDB3|1hovA:233-256 PDB3|1gxdB:233-274PDB3|1ck7A:233-274 PDB3|1qibA:233-260 PDB3|1lkgA:288-329PDB3|1l6jA:288-329 PDB3|1cxwA:291-332 PDB3|1gkdB:230-249PDB3|1gkcA:230-249 PDB3|1j7mA:349-390 PDB3|1e8bA:360-401PDB3|1e88A:360-401 PDB3|1qo6A:360-401 PDB3|2fn2 :420-461PDB3|1pdc :94-134 PDB3|1h8pA:94-134

Fibronectin type II domain is a collagen-binding protein domain.

Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasiscite journal |author=Dean DC, Bowlus CL, Bourgeois S |title=Cloning and analysis of the promotor region of the human fibronectin gene |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue=7 |pages=1876–1880 |year=1987 |pmid=3031656 |doi=10.1073/pnas.84.7.1876] . The major part of the sequence of fibronectin consists of the repetition of three types of domains, which are called type I, II, and IIIcite journal |author=Skorstengaard K, Jensen MS, Sahl P, Petersen TE, Magnusson S |title=Complete primary structure of bovine plasma fibronectin |journal=Eur. J. Biochem. |volume=161 |issue=2 |pages=441–453 |year=1986 |pmid=3780752 |doi=10.1111/j.1432-1033.1986.tb10464.x] .

Type II domain is approximately forty residues long, contains fourconserved cysteines involved in disulfide bonds and is part of the collagen-binding region of fibronectin. In fibronectin the type II domain is duplicated. Type II domains have also been found in a range of proteins including blood coagulation factor XII; bovine seminal plasma proteins PDC-109 (BSP-A1/A2) and BSP-A3cite journal |author=Chretien M, Seidah NG, Manjunath P, Rochemont J, Sairam MR |title=Complete amino acid sequence of BSP-A3 from bovine seminal plasma. Homology to PDC-109 and to the collagen-binding domain of fibronectin |journal=Biochem. J. |volume=243 |issue=1 |pages=195–203 |year=1987 |pmid=3606570] ; cation-independent mannose-6-phosphate receptorcite journal |author=Kornfeld S |title=Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors |journal=Annu. Rev. Biochem. |volume=61 |issue= |pages=307–330 |year=1992 |pmid=1323236 |doi=10.1146/annurev.bi.61.070192.001515] ; mannose receptor of macrophagescite journal |author=Drickamer K, Taylor ME, Conary JT, Lennartz MR, StahlPD |title=Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains|journal=J. Biol. Chem. |volume=265 |issue=21 |pages=12156–12162 |year=1990 |pmid=2373685] ; 180 Kd secretory phospholipase A2 receptorcite journal |author=Lazdunski M, Barhanin J, Lambeau G, Ancian P |title=Cloning and expression of a membrane receptor for secretory phospholipases A2 |journal=J. Biol. Chem. |volume=269 |issue=3|pages=1575–1578 |year=1994 |pmid=8294398] . DEC-205 receptorcite journal |author=Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, Nussenzweig MC |title=The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing |journal=Nature |volume=375 |issue=6527 |pages=151–155 |year=1995 |pmid=7753172 |doi=10.1038/375151a0] ; 72 Kd and 92 Kd type IV collagenase (EC number|3.4.24.24)cite journal |author=Grant GA, Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Seltzer JL, Kronberger A, Bauer EA, Goldberg GI, He CS |title=H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen |journal=J. Biol. Chem. |volume=263 |issue=14 |pages=6579–6587 |year=1988 |pmid=2834383] ; and hepatocyte growth factor activatorcite journal |author=Miyazawa K,Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N |title=Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII |journal=J. Biol. Chem. |volume=268 |issue=14 |pages=10024–10028 |year=1993 |pmid=7683665] .

Human proteins containing this domain

BSPH1; ELSPBP1; F12; FN1; HGFAC; IGF2R; LY75; MMP2;
MMP9; MRC1; MRC1L1; MRC2; PLA2R1; SEL1L;

References

External links

* [http://www.expasy.org/cgi-bin/nicedoc.pl?PDOC00022 Fibronectin type-II collagen-binding domain] in PROSITE