Alpha,alpha-trehalose-phosphate synthase (UDP-forming)

In enzymology, an alpha,alpha-trehalose-phosphate synthase (UDP-forming) (EC number|2.4.1.15) is an enzyme that catalyzes the chemical reaction

:UDP-glucose + D-glucose 6-phosphate $ightleftharpoons$ UDP + alpha,alpha-trehalose 6-phosphate

Thus, the two substrates of this enzyme are UDP-glucose and D-glucose 6-phosphate, whereas its two products are UDP and alpha,alpha'-trehalose 6-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase. Other names in common use include UDP-glucose-glucose-phosphate glucosyltransferase, trehalosephosphate-UDP glucosyltransferase, UDP-glucose-glucose-phosphate glucosyltransferase, alpha,alpha-trehalose phosphate synthase (UDP-forming), phosphotrehalose-uridine diphosphate transglucosylase, trehalose 6-phosphate synthase, trehalose 6-phosphate synthetase, trehalose phosphate synthase, trehalose phosphate synthetase, trehalose phosphate-uridine diphosphate glucosyltransferase, trehalose-P synthetase, transglucosylase, and uridine diphosphoglucose phosphate glucosyltransferase. This enzyme participates in starch and sucrose metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GZ5, PDB link|1UQT, and PDB link|1UQU.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9030-07-3."

Gene Ontology (GO) codes