Fungal mating pheromone receptors

Fungal mating pheromone receptors

Pfam_box
Symbol = STE2
Name = Fungal pheromone mating factor STE2 GPCR


width =
caption =
Pfam= PF02116
InterPro= IPR000366
SMART=
Prosite =
SCOP = 1pjd
TCDB =
OPM family=
OPM protein=
PDB=PDB3|1pjdA:253-269

Fungal pheromone mating factor receptors form a distinct family of G-protein coupled receptors.

Mating factor receptors, STE2 and STE3 are integral membrane proteins that may be involved in the response to mating factors on the cell membranecite journal |author=Nakayama N, Miyajima A, Arai K |title=Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae |journal=EMBO J. |volume=4 |issue=|pages=2643–2648 |year=1985] cite journal |author=Burkholder AC, Hartwell LH |title=The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene |journal=Nucleic Acids Res. |volume=13 |issue=23 |pages=8463–8475 |year=1985 |pmid=3001640 |doi=10.1093/nar/13.23.8463] cite journal |author=Herskowitz I, Marsh L |title=STE2 protein of Saccharomyces kluyveri is a member of the rhodopsin/beta-adrenergic receptor family and is responsible for recognition of the peptide ligand alpha factor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue=11 |pages=3855–3859 |year=1988 |pmid=2836861 |doi=10.1073/pnas.85.11.3855] . The amino acid sequences of both receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins.

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