YWHAQ

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide, also known as YWHAQ, is a human gene.

PBB_Summary
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summary_text = This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [cite web | title = Entrez Gene: YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10971| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013
*cite journal | author=Calinisan V, Gravem D, Chen RP, "et al." |title=New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. |journal=Front. Biosci. |volume=11 |issue= |pages= 1646–66 |year= 2006 |pmid= 16368544 |doi=
*cite journal | author=Nielsen PJ |title=Primary structure of a human protein kinase regulator protein. |journal=Biochim. Biophys. Acta |volume=1088 |issue= 3 |pages= 425–8 |year= 1991 |pmid= 2015305 |doi=
*cite journal | author=Bonnefoy-Bérard N, Liu YC, von Willebrand M, "et al." |title=Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10142–6 |year= 1995 |pmid= 7479742 |doi=
*cite journal | author=Xiao B, Smerdon SJ, Jones DH, "et al." |title=Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. |journal=Nature |volume=376 |issue= 6536 |pages= 188–91 |year= 1995 |pmid= 7603573 |doi= 10.1038/376188a0
*cite journal | author=Leffers H, Madsen P, Rasmussen HH, "et al." |title=Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. |journal=J. Mol. Biol. |volume=231 |issue= 4 |pages= 982–98 |year= 1993 |pmid= 8515476 |doi= 10.1006/jmbi.1993.1346
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Liu YC, Elly C, Yoshida H, "et al." |title=Activation-modulated association of 14-3-3 proteins with Cbl in T cells. |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14591–5 |year= 1996 |pmid= 8663231 |doi=
*cite journal | author=Papin C, Denouel A, Calothy G, Eychène A |title=Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system. |journal=Oncogene |volume=12 |issue= 10 |pages= 2213–21 |year= 1996 |pmid= 8668348 |doi=
*cite journal | author=Zha J, Harada H, Yang E, "et al." |title=Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) |journal=Cell |volume=87 |issue= 4 |pages= 619–28 |year= 1997 |pmid= 8929531 |doi=
*cite journal | author=Suzuki Y, Demoliere C, Kitamura D, "et al." |title=HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. |journal=J. Immunol. |volume=158 |issue= 6 |pages= 2736–44 |year= 1997 |pmid= 9058808 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Dubois T, Rommel C, Howell S, "et al." |title=14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 28882–8 |year= 1997 |pmid= 9360956 |doi=
*cite journal | author=Hsu SY, Kaipia A, Zhu L, Hsueh AJ |title=Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. |journal=Mol. Endocrinol. |volume=11 |issue= 12 |pages= 1858–67 |year= 1997 |pmid= 9369453 |doi=
*cite journal | author=Brunati AM, Donella-Deana A, James P, "et al." |title=Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 7557–64 |year= 1999 |pmid= 10066823 |doi=
*cite journal | author=Hausser A, Storz P, Link G, "et al." |title=Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins. |journal=J. Biol. Chem. |volume=274 |issue= 14 |pages= 9258–64 |year= 1999 |pmid= 10092600 |doi=
*cite journal | author=Finlin BS, Andres DA |title=Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins. |journal=Arch. Biochem. Biophys. |volume=368 |issue= 2 |pages= 401–12 |year= 1999 |pmid= 10441394 |doi= 10.1006/abbi.1999.1316
*cite journal | author=Chow CW, Davis RJ |title=Integration of calcium and cyclic AMP signaling pathways by 14-3-3. |journal=Mol. Cell. Biol. |volume=20 |issue= 2 |pages= 702–12 |year= 2000 |pmid= 10611249 |doi=
*cite journal | author=Mori H, Inoue M, Yano M, "et al." |title=14-3-3tau associates with a translational control factor FKBP12-rapamycin-associated protein in T-cells after stimulation by pervanadate. |journal=FEBS Lett. |volume=467 |issue= 1 |pages= 61–4 |year= 2000 |pmid= 10664457 |doi=
*cite journal | author=Mils V, Baldin V, Goubin F, "et al." |title=Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase. |journal=Oncogene |volume=19 |issue= 10 |pages= 1257–65 |year= 2000 |pmid= 10713667 |doi= 10.1038/sj.onc.1203419

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