Glutamine-fructose-6-phosphate transaminase (isomerizing)

In enzymology, a glutamine-fructose-6-phosphate transaminase (isomerizing) (EC number|2.6.1.16) is an enzyme that catalyzes the chemical reaction

:L-glutamine + D-fructose 6-phosphate $ightleftharpoons$ L-glutamate + D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are L-glutamine and D-fructose 6-phosphate, whereas its two products are L-glutamate and D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:D-fructose-6-phosphate isomerase (deaminating). Other names in common use include hexosephosphate aminotransferase, glucosamine-6-phosphate isomerase (glutamine-forming), glutamine-fructose-6-phosphate transaminase (isomerizing), D-fructose-6-phosphate amidotransferase, glucosaminephosphate isomerase, glucosamine 6-phosphate synthase, and GlcN6P synthase. This enzyme participates in glutamate metabolism and aminosugars metabolism.

tructural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1JXA, PDB link|1MOQ, PDB link|1MOR, PDB link|1MOS, PDB link|1XFF, PDB link|1XFG, PDB link|2BPL, PDB link|2J6H, PDB link|2POC, PDB link|2PUT, PDB link|2PUV, and PDB link|2PUW.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9030-45-9."

Gene Ontology (GO) codes