Trans-octaprenyltranstransferase

In enzymology, a trans-octaprenyltranstransferase (EC number|2.5.1.11) is an enzyme that catalyzes the chemical reaction

:all-trans-octaprenyl diphosphate + isopentenyl diphosphate $ightleftharpoons$ diphosphate + all-trans-nonaprenyl diphosphate

Thus, the two substrates of this enzyme are all-trans-octaprenyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-nonaprenyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is (E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase. Other names in common use include all-trans-nonaprenyl-diphosphate synthase, solanesyl-diphosphate synthase, solanesyl pyrophosphate synthetase, SPP synthase, nonaprenyl pyrophosphate synthetase, polyprenylpyrophosphate synthetase, terpenoidallyltransferase, terpenyl pyrophosphate synthetase, trans-octaprenyltranstransferase, and trans-prenyltransferase. This enzyme participates in biosynthesis of steroids.

tructural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1V4E, PDB link|1V4H, PDB link|1V4I, PDB link|1V4J, PDB link|1V4K, PDB link|1VG2, PDB link|1VG3, PDB link|1VG4, PDB link|1VG6, PDB link|1VG7, PDB link|1WKZ, PDB link|1WL0, PDB link|1WL1, PDB link|1WL2, PDB link|1WL3, and PDB link|2AZL.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|64763-52-6."

Gene Ontology (GO) codes