Gamma-glutamylcyclotransferase

In enzymology, a gamma-glutamylcyclotransferase (EC number|2.3.2.4) is an enzyme that catalyzes the chemical reaction

:(5-L-glutamyl)-L-amino acid $ightleftharpoons$ 5-oxoproline + L-amino acid

Hence, this enzyme has one substrate, (5-L-glutamyl)-L-amino acid, and two products, 5-oxoproline and L-amino acid.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing). Other names in common use include gamma-glutamyl-amino acid cyclotransferase, gamma-L-glutamylcyclotransferase, and L-glutamic cyclase. This enzyme participates in glutathione metabolism.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2PN7 and PDB link|2RBH.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9045-44-7."

Gene Ontology (GO) codes