Acetyl-CoA C-acetyltransferase

In enzymology, an acetyl-CoA C-acetyltransferase (EC number|2.3.1.9) is an enzyme that catalyzes the chemical reaction

:2 acetyl-CoA $$ightleftharpoons CoA + acetoacetyl-CoA

Hence, this enzyme has one substrate, acetyl-CoA, and two products, CoA and acetoacetyl-CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:acetyl-CoA C-acetyltransferase. Other names in common use include acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading] , 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, and thiolase II. This enzyme participates in 10 metabolic pathways: fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, benzoate degradation via coa ligation, propanoate metabolism, butanoate metabolism, and two-component system - general.

tructural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DLU, PDB link|1DLV, PDB link|1DM3, PDB link|1M1O, PDB link|1M1T, PDB link|1M3K, PDB link|1M3Z, PDB link|1M4S, PDB link|1M4T, PDB link|1NL7, PDB link|1OU6, PDB link|1QFL, PDB link|1WL4, PDB link|1WL5, PDB link|2F2S, PDB link|2IB7, PDB link|2IB8, PDB link|2IB9, PDB link|2IBU, PDB link|2IBW, and PDB link|2IBY.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9027-46-7."

Gene Ontology (GO) codes