Imidazolonepropionase

In enzymology, an imidazolonepropionase (EC number|3.5.2.7) is an enzyme that catalyzes the chemical reaction

:(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H₂O $ightleftharpoons$ N-formimidoyl-L-glutamate + H⁺

Thus, the two substrates of this enzyme are (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate and H₂O, whereas its two products are N-formimidoyl-L-glutamate and H⁺.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase. Other names in common use include 4(5)-imidazolone-5(4)-propionic acid hydrolase, and imidazolone propionic acid hydrolase. This enzyme participates in histidine metabolism.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2BB0, PDB link|2G3F, PDB link|2GOK, PDB link|2OOF, PDB link|2PUZ, and PDB link|2Q09.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9024-91-3."

Gene Ontology (GO) codes