Glutamin-(asparagin-)ase

In enzymology, a glutamin-(asparagin-)ase (EC number|3.5.1.38) is an enzyme that catalyzes the chemical reaction

:L-glutamine + H₂O $ightleftharpoons$ L-glutamate + NH₃

Thus, the two substrates of this enzyme are L-glutamine and H₂O, whereas its two products are L-glutamate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is L-glutamine(L-asparagine) amidohydrolase. This enzyme participates in 4 metabolic pathways: glutamate metabolism, alanine and aspartate metabolism, d-glutamine and d-glutamate metabolism, and nitrogen metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DJO, PDB link|1DJP, and PDB link|4PGA.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|39335-03-0."

Gene Ontology (GO) codes