5-oxoprolinase (ATP-hydrolysing)

In enzymology, a 5-oxoprolinase (ATP-hydrolysing) (EC number|3.5.2.9) is an enzyme that catalyzes the chemical reaction

:ATP + 5-oxo-L-proline + 2 H₂O $ightleftharpoons$ ADP + phosphate + L-glutamate

The 3 substrates of this enzyme are ATP, 5-oxo-L-proline, and H₂O, whereas its 3 products are ADP, phosphate, and L-glutamate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 5-oxo-L-proline amidohydrolase (ATP-hydrolysing). Other names in common use include pyroglutamase (ATP-hydrolysing), oxoprolinase, pyroglutamase, 5-oxoprolinase, pyroglutamate hydrolase, pyroglutamic hydrolase, L-pyroglutamate hydrolase, 5-oxo-L-prolinase, and pyroglutamase. This enzyme participates in glutathione metabolism.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9075-46-1."

Gene Ontology (GO) codes