Ribosylpyrimidine nucleosidase

In enzymology, a ribosylpyrimidine nucleosidase (EC number|3.2.2.8) is an enzyme that catalyzes the chemical reaction

:a pyrimidine nucleoside + H₂O $ightleftharpoons$ D-ribose + a pyrimidine base

Thus, the two substrates of this enzyme are pyrimidine nucleoside and H₂O, whereas its two products are D-ribose and pyrimidine base.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is pyrimidine-nucleoside ribohydrolase. Other names in common use include N-ribosylpyrimidine nucleosidase, pyrimidine nucleosidase, N-ribosylpyrimidine ribohydrolase, pyrimidine nucleoside hydrolase, RihB, YeiK, and nucleoside ribohydrolase. This enzyme participates in purine metabolism and pyrimidine metabolism.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1Q8F and PDB link|1YOE.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37288-60-1."

Gene Ontology (GO) codes