Adenosylhomocysteine nucleosidase

In enzymology, an adenosylhomocysteine nucleosidase (EC number|3.2.2.9) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-homocysteine + H₂O $ightleftharpoons$ S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Thus, the two substrates of this enzyme are S-adenosyl-L-homocysteine and H₂O, whereas its two products are S-(5-deoxy-D-ribos-5-yl)-L-homocysteine and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is S-adenosyl-L-homocysteine homocysteinylribohydrolase. Other names in common use include S-adenosylhomocysteine hydrolase (ambiguous), S-adenosylhomocysteine nucleosidase, 5'-methyladenosine nucleosidase, S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase, and AdoHcy/MTA nucleosidase. This enzyme participates in methionine metabolism.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1JYS, PDB link|1NC1, PDB link|1NC3, PDB link|1Y6Q, PDB link|1Y6R, PDB link|1Z5N, PDB link|1Z5O, and PDB link|1Z5P.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9055-10-1."

Gene Ontology (GO) codes