INHA

Inhibin, alpha, also known as INHA, is a human gene.

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summary_text = The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. [cite web | title = Entrez Gene: INHA inhibin, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3623| accessdate = ]

ee also

* Inhibin

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mellor SL, Richards MG, Pedersen JS, "et al." |title=Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 3 |pages= 969–75 |year= 1998 |pmid= 9506758 |doi=
*cite journal | author=Munz B, Hübner G, Tretter Y, "et al." |title=A novel role of activin in inflammation and repair. |journal=J. Endocrinol. |volume=161 |issue= 2 |pages= 187–93 |year= 1999 |pmid= 10320815 |doi=
*cite journal | author=Welt C, Sidis Y, Keutmann H, Schneyer A |title=Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. |journal=Exp. Biol. Med. (Maywood) |volume=227 |issue= 9 |pages= 724–52 |year= 2002 |pmid= 12324653 |doi=
*cite journal | author=Shav-Tal Y, Zipori D |title=The role of activin a in regulation of hemopoiesis. |journal=Stem Cells |volume=20 |issue= 6 |pages= 493–500 |year= 2003 |pmid= 12456957 |doi=
*cite journal | author=Shao L, Frigon NL, Young AL, "et al." |title=Effect of activin A on globin gene expression in purified human erythroid progenitors. |journal=Blood |volume=79 |issue= 3 |pages= 773–81 |year= 1992 |pmid= 1310063 |doi=
*cite journal | author=Vannelli GB, Barni T, Forti G, "et al." |title=Immunolocalization of inhibin alpha-subunit in the human testis. A light- and electron-microscopy study. |journal=Cell Tissue Res. |volume=269 |issue= 2 |pages= 221–7 |year= 1992 |pmid= 1423490 |doi=
*cite journal | author=Matzuk MM, Finegold MJ, Su JG, "et al." |title=Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. |journal=Nature |volume=360 |issue= 6402 |pages= 313–9 |year= 1992 |pmid= 1448148 |doi= 10.1038/360313a0
*cite journal | author=Shimonaka M, Inouye S, Shimasaki S, Ling N |title=Follistatin binds to both activin and inhibin through the common subunit. |journal=Endocrinology |volume=128 |issue= 6 |pages= 3313–5 |year= 1991 |pmid= 2036994 |doi=
*cite journal | author=Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH |title=Activin B: precursor sequences, genomic structure and in vitro activities. |journal=Mol. Endocrinol. |volume=3 |issue= 9 |pages= 1352–8 |year= 1990 |pmid= 2575216 |doi=
*cite journal | author=Barton DE, Yang-Feng TL, Mason AJ, "et al." |title=Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice. |journal=Genomics |volume=5 |issue= 1 |pages= 91–9 |year= 1989 |pmid= 2767687 |doi=
*cite journal | author=Lappöhn RE, Burger HG, Bouma J, "et al." |title=Inhibin as a marker for granulosa-cell tumors. |journal=N. Engl. J. Med. |volume=321 |issue= 12 |pages= 790–3 |year= 1989 |pmid= 2770810 |doi=
*cite journal | author=Mayo KE, Cerelli GM, Spiess J, "et al." |title=Inhibin A-subunit cDNAs from porcine ovary and human placenta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 16 |pages= 5849–53 |year= 1986 |pmid= 3016724 |doi=
*cite journal | author=Ramasharma K, Li CH |title=Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 11 |pages= 3595–8 |year= 1987 |pmid= 3035540 |doi=
*cite journal | author=Murata M, Eto Y, Shibai H, "et al." |title=Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 8 |pages= 2434–8 |year= 1988 |pmid= 3267209 |doi=
*cite journal | author=Burger HG, Igarashi M |title=Inhibin: definition and nomenclature, including related substances. |journal=Endocrinology |volume=122 |issue= 4 |pages= 1701–2 |year= 1988 |pmid= 3345731 |doi=
*cite journal | author=Mason AJ, Niall HD, Seeburg PH |title=Structure of two human ovarian inhibins. |journal=Biochem. Biophys. Res. Commun. |volume=135 |issue= 3 |pages= 957–64 |year= 1986 |pmid= 3754442 |doi=
*cite journal | author=Stewart AG, Milborrow HM, Ring JM, "et al." |title=Human inhibin genes. Genomic characterisation and sequencing. |journal=FEBS Lett. |volume=206 |issue= 2 |pages= 329–34 |year= 1986 |pmid= 3758355 |doi=
*cite journal | author=Xu J, McKeehan K, Matsuzaki K, McKeehan WL |title=Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 6308–13 |year= 1995 |pmid= 7890768 |doi=
*cite journal | author=Nishihara T, Okahashi N, Ueda N |title=Activin A induces apoptotic cell death. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 2 |pages= 985–91 |year= 1994 |pmid= 8267637 |doi= 10.1006/bbrc.1993.2576
*cite journal | author=Mason AJ, Farnworth PG, Sullivan J |title=Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A. |journal=Mol. Endocrinol. |volume=10 |issue= 9 |pages= 1055–65 |year= 1997 |pmid= 8885240 |doi=

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