PUVA

PUVA

PUVA is a Psoralen + UVA treatment for Eczema, Psoriasis and Vitiligo, and mycosis fungoides [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8507078&dopt=Abstract] . The Psoralen is applied or taken orally to sensitize the skin, then the skin is exposed to UVA. Long term use has been associated with higher rates of skin cancer. [http://www.medicinenet.com/script/main/art.asp?articlekey=548]

Psoralens are photosensitizing agents found in plants. They have been known since ancient Egypt but have only been available in a chemically synthesized form since the 1970s. Psoralens are taken systemically or can be applied directly to the skin. The psoralens allow a relatively lower dose of UVA to be used. When they are combined with exposure to UVA in PUVA, they are highly effective at clearing psoriasis. Like UVB light treatments, the reason remains unclear, though investigators speculate there may be similar effects on cell turnover and the skin's immune response.

Choosing the proper dose for PUVA is similar to the procedure followed with UVB. The physician can choose a dose based on the patient's skin type. Often, however, a small area of the patient's skin will be exposed to UVA after ingestion of psoralen. The dose of UVA that produces uniform redness 72 hours later, called the minimum phototoxic dose (MPD), becomes the starting dose for treatment.

Some patients experience nausea and itching after ingesting the psoralen compound. For these patients PUVA bath therapy may be a good option.

ee also

* Psoriasis Photochemotherapy
* Light therapy


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Look at other dictionaries:

  • PUVA — steht als Abkürzung für Psoralen plus UV A, wobei mit dieser Kombination von langwelligem UV Licht und dem als Naturstoff in den ätherischen Ölen verschiedener Pflanzen vorkommenden Psoralen dessen photosensibilisierende Eigenschaften zu… …   Deutsch Wikipedia

  • PUVA — stands for psoralen and ultraviolet A (UVA) therapy in which the patient is exposed first to psoralens (drugs containing chemicals that react with ultraviolet light to cause darkening of the skin) and then to UVA light. PUVA is, for instance,… …   Medical dictionary

  • PUVA — Abreviatura de un tratamiento de la psoriasis que consiste en un medicamente llamado psoraleno y luz ultravioleta de longitud de onda A (larga). Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A …   Diccionario médico

  • PUVA — PUVA,   Abkürzung für Psoralene plus UV A (Blacklight Therapie) …   Universal-Lexikon

  • PUVA — sigla Psoralene e raggi Ultravioletti di tipo A, nei trattamenti di fotochemioterapia …   Dizionario italiano

  • PUVA — photochemotherapy psoralen + ultraviolet A: the combination of a psoralen (a light sensitive drug) and exposure to long wave (315–400 nm) ultraviolet light (UVA). It was used in the East in ancient times, with natural sunlight as the light source …   The new mediacal dictionary

  • PUVA — a therapy for psoriasis combining the oral drug psoralen and high intensity long wave ultraviolet light. [P(SORALEN) + UV A ultraviolet light of a wavelength between 320 and 400 nanometers] * * * PUVA «POO vuh», noun. a method of treating… …   Useful english dictionary

  • PUVA — a therapy for psoriasis combining the oral drug psoralen and high intensity long wave ultraviolet light. [P(SORALEN) + UV A ultraviolet light of a wavelength between 320 and 400 nanometers] * * * …   Universalium

  • PUVA — Psoralens plus ultraviolet light of the A wavelength (Psoralogenos más radiación ultravioleta de longitud de onda A) …   Diccionario de siglas médicas y otras abreviaturas

  • PUVA — • psoralen ultraviolet A range …   Dictionary of medical acronyms & abbreviations

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