Carboxymethylenebutenolidase

In enzymology, a carboxymethylenebutenolidase (EC number|3.1.1.45) is an enzyme that catalyzes the chemical reaction

:4-carboxymethylenebut-2-en-4-olide + H₂O $ightleftharpoons$ 4-oxohex-2-enedioate

Thus, the two substrates of this enzyme are 4-carboxymethylenebut-2-en-4-olide and H₂O, whereas its product is 4-oxohex-2-enedioate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 4-carboxymethylenebut-2-en-4-olide lactonohydrolase. Other names in common use include maleylacetate enol-lactonase, dienelactone hydrolase, and carboxymethylene butenolide hydrolase. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,4-dichlorobenzene degradation.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DIN, PDB link|1GGV, PDB link|1ZI6, PDB link|1ZI8, PDB link|1ZI9, PDB link|1ZIC, PDB link|1ZIX, PDB link|1ZIY, PDB link|1ZJ4, and PDB link|1ZJ5.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|76689-22-0."

Gene Ontology (GO) codes