Aminoacyl-tRNA hydrolase

Aminoacyl-tRNA hydrolase

In enzymology, an aminoacyl-tRNA hydrolase (EC number|3.1.1.29) is an enzyme that catalyzes the chemical reaction

:N-Substituted aminoacyl-tRNA + H2O ightleftharpoons N-substituted amino acid + tRNA

Thus, the two substrates of this enzyme are N-Substituted aminoacyl-tRNA and H2O, whereas its two products are N-substituted amino acid and tRNA.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is aminoacyl-tRNA aminoacylhydrolase. Other names in common use include aminoacyl-transfer ribonucleate hydrolase, N-substituted aminoacyl transfer RNA hydrolase, and peptidyl-tRNA hydrolase.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1RYB, PDB link|1WN2, PDB link|1XTY, PDB link|2D3K, PDB link|2E1B, PDB link|2PTH, PDB link|2Z2I, PDB link|2Z2J, and PDB link|2Z2K.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9054-98-2."

Gene Ontology (GO) codes


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