Phosphoribosyl-ATP diphosphatase

In enzymology, a phosphoribosyl-ATP diphosphatase (EC number|3.6.1.31) is an enzyme that catalyzes the chemical reaction

:1-(5-phosphoribosyl)-ATP + H₂O $ightleftharpoons$ 1-(5-phosphoribosyl)-AMP + diphosphate

Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H₂O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase. This enzyme participates in histidine metabolism. It employs one cofactor, H+.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1Y6X, PDB link|1YVW, PDB link|1YXB, and PDB link|2A7W.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|69553-55-5."

Gene Ontology (GO) codes