H+-exporting ATPase

In enzymology, a H+-exporting ATPase (EC number|3.6.3.6) is an enzyme that catalyzes the chemical reaction

:ATP + H₂O + H⁺in $ightleftharpoons$ ADP + phosphate + H⁺out

The 3 substrates of this enzyme are ATP, H₂O, and H⁺, whereas its 3 products are ADP, phosphate, and H⁺.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (H+-exporting). Other names in common use include proton-translocating ATPase, yeast plasma membrane H+-ATPase, yeast plasma membrane ATPase, and ATP phosphohydrolase. This enzyme participates in oxidative phosphorylation. It employs one cofactor, H+.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1MHS.

References

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External links

Gene Ontology (GO) codes