EDG8

EDG8

EDG8 (endothelial differentiation gene 1) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.cite web | title = Entrez Gene: EDG8 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53637| accessdate = ]

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ee also

* Lysophospholipid receptor

References

Further reading

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*cite journal | author=Im DS, Heise CE, Ancellin N, "et al." |title=Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14281–6 |year= 2000 |pmid= 10799507 |doi=
*cite journal | author=Malek RL, Toman RE, Edsall LC, "et al." |title=Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors. |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5692–9 |year= 2001 |pmid= 11069896 |doi= 10.1074/jbc.M003964200
*cite journal | author=Hla T |title=Sphingosine 1-phosphate receptors. |journal= |volume=64 |issue= 1-4 |pages= 135–142 |year= |pmid= 11331101 |doi=
*cite journal | author=Im DS, Clemens J, Macdonald TL, Lynch KR |title=Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. |journal=Biochemistry |volume=40 |issue= 46 |pages= 14053–60 |year= 2001 |pmid= 11705398 |doi=
*cite journal | author=Takeda S, Kadowaki S, Haga T, "et al." |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=
*cite journal | author=Niedernberg A, Scherer CR, Busch AE, Kostenis E |title=Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. |journal=Biochem. Pharmacol. |volume=64 |issue= 8 |pages= 1243–50 |year= 2002 |pmid= 12234605 |doi=
*cite journal | author=Kothapalli R, Kusmartseva I, Loughran TP |title=Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. |journal=Biochim. Biophys. Acta |volume=1579 |issue= 2-3 |pages= 117–23 |year= 2003 |pmid= 12427546 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Vogler R, Sauer B, Kim DS, "et al." |title=Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. |journal=J. Invest. Dermatol. |volume=120 |issue= 4 |pages= 693–700 |year= 2003 |pmid= 12648236 |doi= 10.1046/j.1523-1747.2003.12096.x
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ulfig N, Briese M |title=Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers. |journal=Acta Histochem. |volume=106 |issue= 5 |pages= 373–8 |year= 2005 |pmid= 15530552 |doi= 10.1016/j.acthis.2004.08.002
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1338 IUPHAR GPCR Database - Lysophospholipid receptors]
*

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