EDG3

EDG3 (endothelial differentiation gene 1) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.cite web | title = Entrez Gene: EDG3 endothelial differentiation, sphingolipid G-protein-coupled receptor, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1903| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.cite web | title = Entrez Gene: EDG3 endothelial differentiation, sphingolipid G-protein-coupled receptor, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1903| accessdate = ]

ee also

* Lysophospholipid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hla T, Lee MJ, Ancellin N, "et al." |title=Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. |journal=Ann. N. Y. Acad. Sci. |volume=905 |issue= |pages= 16–24 |year= 2000 |pmid= 10818438 |doi=
*cite journal | author=Spiegel S |title=Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. |journal=Ann. N. Y. Acad. Sci. |volume=905 |issue= |pages= 54–60 |year= 2000 |pmid= 10818441 |doi=
*cite journal | author=Watsky MA, Griffith M, Wang DA, Tigyi GJ |title=Phospholipid growth factors and corneal wound healing. |journal=Ann. N. Y. Acad. Sci. |volume=905 |issue= |pages= 142–58 |year= 2000 |pmid= 10818450 |doi=
*cite journal | author=Takuwa Y |title= [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 4 Suppl |pages= 496–502 |year= 2002 |pmid= 11915348 |doi=
*cite journal | author=Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, "et al." |title=A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils. |journal=Mol. Pharmacol. |volume=49 |issue= 6 |pages= 956–61 |year= 1996 |pmid= 8649355 |doi=
*cite journal | author=Yamaguchi F, Tokuda M, Hatase O, Brenner S |title=Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. |journal=Biochem. Biophys. Res. Commun. |volume=227 |issue= 2 |pages= 608–14 |year= 1996 |pmid= 8878560 |doi= 10.1006/bbrc.1996.1553
*cite journal | author=An S, Bleu T, Huang W, "et al." |title=Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. |journal=FEBS Lett. |volume=417 |issue= 3 |pages= 279–82 |year= 1998 |pmid= 9409733 |doi=
*cite journal | author=Van Brocklyn JR, Tu Z, Edsall LC, "et al." |title=Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. |journal=J. Biol. Chem. |volume=274 |issue= 8 |pages= 4626–32 |year= 1999 |pmid= 9988698 |doi=
*cite journal | author=Zhang Q, Peyruchaud O, French KJ, "et al." |title=Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway. |journal=Blood |volume=93 |issue= 9 |pages= 2984–90 |year= 1999 |pmid= 10216094 |doi=
*cite journal | author=Ancellin N, Hla T |title=Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 18997–9002 |year= 1999 |pmid= 10383399 |doi=
*cite journal | author=Windh RT, Lee MJ, Hla T, "et al." |title=Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27351–8 |year= 1999 |pmid= 10488065 |doi=
*cite journal | author=Goetzl EJ, Dolezalova H, Kong Y, "et al." |title=Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. |journal=Cancer Res. |volume=59 |issue= 20 |pages= 5370–5 |year= 1999 |pmid= 10537322 |doi=
*cite journal | author=Lee MJ, Thangada S, Claffey KP, "et al." |title=Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. |journal=Cell |volume=99 |issue= 3 |pages= 301–12 |year= 1999 |pmid= 10555146 |doi=
*cite journal | author=An S, Zheng Y, Bleu T |title=Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 288–96 |year= 2000 |pmid= 10617617 |doi=
*cite journal | author=Orlati S, Porcelli AM, Hrelia S, "et al." |title=Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. |journal=Arch. Biochem. Biophys. |volume=375 |issue= 1 |pages= 69–77 |year= 2000 |pmid= 10683250 |doi= 10.1006/abbi.1999.1589
*cite journal | author=Lee H, Goetzl EJ, An S |title=Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. |journal=Am. J. Physiol., Cell Physiol. |volume=278 |issue= 3 |pages= C612–8 |year= 2000 |pmid= 10712250 |doi=
*cite journal | author=Kimura T, Watanabe T, Sato K, "et al." |title=Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. |journal=Biochem. J. |volume=348 Pt 1 |issue= |pages= 71–6 |year= 2000 |pmid= 10794715 |doi=

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1338 IUPHAR GPCR Database - Lysophospholipid receptors]
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