Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)

In enzymology, a bis(5'-nucleosyl)-tetraphosphatase (symmetrical) (EC number|3.6.1.41) is an enzyme that catalyzes the chemical reaction

:P₁,P₄-bis(5'-adenosyl) tetraphosphate + H₂O $ightleftharpoons$ 2 ADP

Thus, the two substrates of this enzyme are P1,P4-bis(5'-adenosyl) tetraphosphate and H₂O, whereas its product is ADP.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase. Other names in common use include diadenosinetetraphosphatase (symmetrical), dinucleosidetetraphosphatasee (symmetrical), symmetrical diadenosine tetraphosphate hydrolase, adenosine tetraphosphate phosphodiesterase, Ap4A hydrolase, bis(5'-adenosyl) tetraphosphatase, diadenosine tetraphosphate hydrolase, diadenosine polyphosphate hydrolase, diadenosine 5',5-P1,P4-tetraphosphatase, diadenosinetetraphosphatase (symmetrical), 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate, and nucleosidebisphosphohydrolase"'. This enzyme participates in purine metabolism.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2DFJ and PDB link|2QJC.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|85638-48-8."

Gene Ontology (GO) codes