Acylphosphatase

Pfam_box
Symbol = Acylphosphatase
Name = Acylphosphatase


width = 250
caption = PDB rendering based on PDB2|1APS.
Pfam = PF00708
InterPro=IPR001792
SMART=
PROSITE= PDOC00136
SCOP = 1aps
TCDB =
OPM family =
OPM protein =
PDB = PDB2|2GV1, PDB2|1APS, PDB2|2FHM, PDB2|1Y9O, PDB2|1URR, PDB2|1W2I, PDB2|2ACY, PDB2|2BJD, PDB2|1V3Z, PDB2|2HLT, PDB2|2HLU, PDB2|2BJE, PDB2|3BR8, PDB2|1ULRprotein
Name = acylphosphatase 1, erythrocyte (common) type
caption =


width =
HGNCid = 179
Symbol = ACYP1
AltSymbols =
EntrezGene = 97
OMIM = 600875
RefSeq = NM_001107
UniProt = P07311
PDB =
ECnumber = 3.6.1.7
Chromosome = 14
Arm = q
Band = 24.3
LocusSupplementaryData = protein
Name = acylphosphatase 2, muscle type
caption =


width =
HGNCid = 180
Symbol = ACYP2
AltSymbols =
EntrezGene = 98
OMIM = 102595
RefSeq = NM_138448
UniProt = P14621
PDB =
ECnumber = 3.6.1.7
Chromosome = 2
Arm = p
Band = 16.2
LocusSupplementaryData = In enzymology, an acylphosphatase (EC number|3.6.1.7) is an enzyme that catalyzes the following chemical reaction:cite journal | author = Stefani M, Taddei N, Ramponi G | title = Insights into acylphosphatase structure and catalytic mechanism | journal = Cell. Mol. Life Sci. | volume = 53 | issue = 2 | pages = 141–51 | year = 1997 | month = February | pmid = 9118002 | doi = 10.1007/PL00000585 | url = | issn = ]

Thus, the two substrates of this enzyme are acylphosphate and H₂O, whereas its two products are carboxylate and phosphate.

Function

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is acylphosphate phosphohydrolase. Other names in common use include acetylphosphatase, 1,3-diphosphoglycerate phosphatase, acetic phosphatase, Ho 1-3, and GP 1-3.

This enzyme participates in 3 metabolic pathways:
* glycolysis / gluconeogenesis
* pyruvate metabolism, and
* benzoate degradation via coa ligation.

tructural studies

As of late 2008, 14 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1APS, PDB link|1ULR, PDB link|1URR, PDB link|1V3Z, PDB link|1W2I, PDB link|1Y9O, PDB link|2ACY, PDB link|2BJD, PDB link|2BJE, PDB link|2FHM, PDB link|2GV1, PDB link|2HLT, PDB link|2HLU and PDB link|3BR8.

References

External links

::"The CAS registry number for this enzyme class is CAS registry|9012-34-4."