Trichodiene synthase

In enzymology, a trichodiene synthase (EC number|4.2.3.6) is an enzyme that catalyzes the chemical reaction

:trans,trans-farnesyl diphosphate $ightleftharpoons$ trichodiene + diphosphate

Hence, this enzyme has one substrate, trans,trans-farnesyl diphosphate, and two products, trichodiene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1YJ4, PDB link|1YYQ, PDB link|1YYR, PDB link|1YYS, PDB link|1YYT, PDB link|1YYU, PDB link|2AEK, PDB link|2AEL, and PDB link|2AET.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|101915-76-8."

Gene Ontology (GO) codes