Propanediol dehydratase

In enzymology, a propanediol dehydratase (EC number|4.2.1.28) is an enzyme that catalyzes the chemical reaction

:propane-1,2-diol $ightleftharpoons$ propanal + H₂O

Hence, this enzyme has one substrate, 1,2-propanediol, and two products, propanal and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is propane-1,2-diol hydro-lyase (propanal-forming). Other names in common use include meso-2,3-butanediol dehydrase, diol dehydratase, DL-1,2-propanediol hydro-lyase, diol dehydrase, adenosylcobalamin-dependent diol dehydratase, propanediol dehydrase, coenzyme B12-dependent diol dehydrase, 1,2-propanediol dehydratase, dioldehydratase, and propane-1,2-diol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobamide.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DIO, PDB link|1EEX, PDB link|1EGM, PDB link|1EGV, PDB link|1IWB, PDB link|1UC4, and PDB link|1UC5.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-90-8."

Gene Ontology (GO) codes