Imidazoleglycerol-phosphate dehydratase

In enzymology, an imidazoleglycerol-phosphate dehydratase (EC number|4.2.1.19) is an enzyme that catalyzes the chemical reaction

:D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate $ightleftharpoons$ 3-(imidazol-4-yl)-2-oxopropyl phosphate + H₂O

Hence, this enzyme has one substrate, D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate, and two products, 3-(imidazol-4-yl)-2-oxopropyl phosphate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-erythro-1-(imidazol-4-yl)glycerol-3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming] . Other names in common use include IGP dehydratase, and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase. This enzyme participates in histidine metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1RHY, PDB link|2AE8, and PDB link|2F1D.

References

*

External links

::"The CAS registry number for this enzyme class is CAS registry|9024-35-5."

Gene Ontology (GO) codes