(-)-endo-fenchol synthase

(-)-endo-fenchol synthase
(-)-endo-fenchol synthase
Identifiers
EC number 4.2.3.10
CAS number 117758-41-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a (-)-endo-fenchol synthase (EC 4.2.3.10) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate + H2O \rightleftharpoons (-)-endo-fenchol + diphosphate

Thus, the two substrates of this enzyme are geranyl diphosphate and H2O, whereas its two products are (-)-endo-fenchol and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]. Other names in common use include (-)-endo-fenchol cyclase, and geranyl pyrophosphate:(-)-endo-fenchol cyclase. This enzyme participates in monoterpenoid biosynthesis.

References

  • Croteau R, Miyazaki JH, Wheeler CJ (1989). "Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(-)-endo-fenchol cyclase from fennel (Foeniculum vulgare)". Arch. Biochem. Biophys. 269 (2): 507–16. doi:10.1016/0003-9861(89)90134-3. PMID 2919880. 
  • Croteau R, Satterwhite DM, Wheeler CJ, Felton NM (1988). "Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (-)-endo-fenchol". J. Biol. Chem. 263 (30): 15449–53. PMID 3170591. 


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