Cyclohexyl-isocyanide hydratase

Cyclohexyl-isocyanide hydratase
cyclohexyl-isocyanide hydratase
Identifiers
EC number 4.2.1.103
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cyclohexyl-isocyanide hydratase (EC 4.2.1.103) is an enzyme that catalyzes the chemical reaction

N-cyclohexylformamide \rightleftharpoons cyclohexyl isocyanide + H2O

Hence, this enzyme has one substrate, N-cyclohexylformamide, and two products, cyclohexyl isocyanide and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming). Other names in common use include isonitrile hydratase, and N-cyclohexylformamide hydro-lyase. This enzyme participates in caprolactam degradation.

References

  • Goda M, Hashimoto Y, Shimizu S, Kobayashi M (2001). "Discovery of a novel enzyme, isonitrile hydratase, involved in nitrogen-carbon triple bond cleavage". J. Biol. Chem. 276 (26): 23480–5. doi:10.1074/jbc.M007856200. PMID 11306561. 
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