Cyclohexa-1,5-dienecarbonyl-CoA hydratase

cyclohexa-1,5-dienecarbonyl-CoA hydratase
Identifiers
EC number	4.2.1.100
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a cyclohexa-1,5-dienecarbonyl-CoA hydratase (EC 4.2.1.100) is an enzyme that catalyzes the chemical reaction

6-hydroxycyclohex-1-enecarbonyl-CoA $\rightleftharpoons$ cyclohexa-1,5-dienecarbonyl-CoA + H₂O

Hence, this enzyme has one substrate, 6-hydroxycyclohex-1-enecarbonyl-CoA, and two products, cyclohexa-1,5-dienecarbonyl-CoA and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming). Other names in common use include cyclohexa-1,5-diene-1-carbonyl-CoA hydratase, dienoyl-CoA hydratase, and cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect). This enzyme participates in benzoate degradation via coa ligation.

References

• Laempe D, Eisenreich W, Bacher A, Fuchs G (1998). "Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica". Eur. J. Biochem. 255 (3): 618–27. doi:10.1046/j.1432-1327.1998.2550618.x. PMID 9738901. 
• Harwood CS, Gibson J (1997). "Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?". J. Bacteriol. 179 (2): 301–9. PMC 178697. PMID 8990279. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=178697. 
• Koch J, Eisenreich W, Bacher A, Fuchs G (1993). "Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism". Eur. J. Biochem. 211 (3): 649–61. doi:10.1111/j.1432-1033.1993.tb17593.x. PMID 8436125. 

This EC 4.2 enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: EC 4.2 stubs EC 4.2.1 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? F32 Hartsdown Technology College Look at other dictionaries: List of EC numbers (EC 4) — This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 4.1: Carbon Carbon LyasesEC… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”